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Anti-CD22 [BU59]

Invented by Dr Margaret Goodall at University Of Birmingham

Info

Catalogue Number 153221
Applications FACS IHC
Antigen/Gene or Protein Targets CD22
Synonyms Cluster of differentiation-22; B cell receptor CD22 precursor;
Reactivity Human
Relevance Cluster of differentiation 22 (CD22) is a sugar binding transmembrane protein belonging to the SIGLEC family of lectins, found on the surface of mature B cells and on some immature B cells. It acts as by preventing over activation of the immune system and the development of autoimmune diseases. CD22 which binds specifically to sialic acid with its N terminal immunoglobulin domain, is a member of the immunoglobulin superfamily due to the presence of Ig domains. CD22 function’s as an inhibitory receptor for B cell receptor signalling and is also involved in the B cell trafficking to Peyer's patches in mice.
Host Mouse
Immunogen Tonsil derrived B cells
Subclass IgG1
Strain Balb/c
Research Area Adhesion, Cancer, Cell Signaling & Signal Transduction, Immunology, Stem Cell Biology

References

There are 1 reference entries for this reagent.

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References: 1 entry

Leucocyte Typing V, (1995): edited by S.F. Schlossman, OUP, Oxford.


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References: 1 entry

Leucocyte Typing V, (1995): edited by S.F. Schlossman, OUP, Oxford.


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