Anti-CD22 [BU59]
Invented by Dr Margaret Goodall from University Of Birmingham
Invented at University Of Birmingham
- Datasheet
- References (1)
- Inventor Info
Info
| Catalogue Number | 153221 |
| Applications | FACS IHC |
| Antigen/Gene or Protein Targets | CD22 |
| Synonyms | Cluster of differentiation-22; B cell receptor CD22 precursor; |
| Reactivity | Human |
| Relevance | Cluster of differentiation 22 (CD22) is a sugar binding transmembrane protein belonging to the SIGLEC family of lectins, found on the surface of mature B cells and on some immature B cells. It acts as by preventing over activation of the immune system and the development of autoimmune diseases. CD22 which binds specifically to sialic acid with its N terminal immunoglobulin domain, is a member of the immunoglobulin superfamily due to the presence of Ig domains. CD22 function’s as an inhibitory receptor for B cell receptor signalling and is also involved in the B cell trafficking to Peyer's patches in mice. |
| Host | Mouse |
| Immunogen | Tonsil derrived B cells |
| Subclass | IgG1 |
| Strain | Balb/c |
| Research Area | Adhesion, Cancer, Cell Signaling & Signal Transduction, Immunology, Stem Cell Biology |
