Anti-CD22 [BU59]

Tool Details

*FOR RESEARCH USE ONLY

• Name: Anti-CD22 [BU59]
• Alternate name: Cluster of differentiation-22; B cell receptor CD22 precursor;
• Clone: BU59
• Tool sub type: Primary antibody
• Class: Monoclonal
• Conjugation: Unconjugated
• Strain: Balb/c
• Reactivity: Human
• Host: Mouse
• Application: FACS ; IHC
• Description: Cluster of differentiation 22 (CD22) is a sugar binding transmembrane protein belonging to the SIGLEC family of lectins, found on the surface of mature B cells and on some immature B cells. It acts as by preventing over activation of the immune system and the development of autoimmune diseases. CD22 which binds specifically to sialic acid with its N terminal immunoglobulin domain, is a member of the immunoglobulin superfamily due to the presence of Ig domains. CD22 function’s as an inhibitory receptor for B cell receptor signalling and is also involved in the B cell trafficking to Peyer's patches in mice.
• Immunogen: Tonsil derrived B cells
• Isotype: IgG1

Target Details

• Target: CD22
• Target background: Cluster of differentiation 22 (CD22) is a sugar binding transmembrane protein belonging to the SIGLEC family of lectins, found on the surface of mature B cells and on some immature B cells. It acts as by preventing over activation of the immune system and the development of autoimmune diseases. CD22 which binds specifically to sialic acid with its N terminal immunoglobulin domain, is a member of the immunoglobulin superfamily due to the presence of Ig domains. CD22 function's as an inhibitory receptor for B cell receptor signalling and is also involved in the B cell trafficking to Peyer's patches in mice.

Applications

• Application: FACS ; IHC

Handling

• Format: Liquid
• Concentration: 0.9-1.1 mg/ml
• Unit size: 100 ug
• Storage buffer: PBS with 0.02% azide
• Storage conditions: -15° C to -25° C
• Shipping conditions: Shipping at 4° C

References

• Leucocyte Typing V, (1995): edited by S.F. Schlossman, OUP, Oxford.