Cancer Research Technology
Log in Register
Menu

Anti-HPV16E2, Polyclonal [HPV16E2]

Info

Catalogue Number 153202
Applications IHC WB
Antigen/Gene or Protein Targets HPV16E2
Synonyms Human papillomavirus type 16; Regulatory protein E2
Reactivity Human
Relevance Cervical intraepithelial neoplasia (CIN) is caused by human papillomavirus (HPV) infection and is the precursor to cervical carcinoma. The completion of the HPV productive life cycle depends on the expression of viral proteins. Initiation of the viral productive replication requires expression of the E2 viral protein that cooperates with the E1 viral DNA helicase. A novel and important role for the HPV16-E2 protein in controlling host cell cycle during malignant transformation was recently revealed. Xells expressing HPV16-E2 in vitro were arrested in prophase alongside activation of a sustained DDR signal. In vivo, HPV16-E2 protein is present in cells that express both mitotic and DDR signals specifically in CIN3 lesions, immediate precursors of cancer, suggesting that E2 may be one of the drivers of genomic instability and carcinogenesis in vivo.
Host Rabbit
Immunogen GST-HPV16 E2 (209–365)
Formulation Whole serum
Research Area Cancer, Cell Cycle, Virology

References

There are 4 reference entries for this reagent.

View All References

References: 4 entries

Xue et al. 2015. Oncotarget. 6(33):34979-91. PMID: 26474276.

HPV16-E2 induces prophase arrest and activates the cellular DNA damage response in vitro and in precursor lesions of cervical carcinoma.

Europe PMC ID: 26474276

Xue et al. 2010. Cancer Res. 70(13):5316-25. PMID: 20530671.

HPV16 E2 is an immediate early marker of viral infection, preceding E7 expression in precursor structures of cervical carcinoma.

Europe PMC ID: 20530671


Add a reference

References: 4 entries

Xue et al. 2015. Oncotarget. 6(33):34979-91. PMID: 26474276.

HPV16-E2 induces prophase arrest and activates the cellular DNA damage response in vitro and in precursor lesions of cervical carcinoma.

Xue et al. 2010. Cancer Res. 70(13):5316-25. PMID: 20530671.

HPV16 E2 is an immediate early marker of viral infection, preceding E7 expression in precursor structures of cervical carcinoma.


Add a reference

Inventor Information

No inventors are currently linked to this reagent.

Add an inventor