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Anti-CHIKV [3E7b]

Info

Catalogue Number 153198
Applications ELISA IHC Fn WB
Antigen/Gene or Protein Targets N218 epitope on E2 protein of CHIKV
Synonyms Chikungunya virus
Reactivity Virus
Relevance Chikungunya virus (CHIKV) is known to be transmitted to humans by mosquito vectors, primarily Aedes aegypti and A. albopictus. Symptoms of chikungunya infection generally initiated 4–7 days after the bite of the mosquito vector and usually include high fever, asthenia, chills, headache, diarrhoea, vomiting and rash. CHIKV gained its infamity from the severe outbreak in the Indian Ocean island of La Re’union in 2005-2006, in which 38.2% of the population was infected and 41.5 million people were documented to have experienced hemorrhagic fever manifestations. Since the re-emergence of CHIKV in La Reunion, epidemic outbreaks of CHIKV infection have been reported globally and CHIKV is now considered endemic in 34 countries across Europe, Australia, Asia and Africa. Mouse monoclonal antibodies that are specific to chikungunya virus can be used as a research or diagnostic reagent to detect infection of cells.
Host Mouse
Immunogen Live chikungunya virus
Positive Control Infected BHK cells
Subclass IgM
Myeloma Used Sp2/0-Ag14
Notes Both Anti-CHIKV [3E7b] and Anti-CHIKV [8A2c] bind strongly to native CHIKV surface and potently neutralize CHIKV replication.
Research Area Parasitology, Virology

References

There are 2 reference entries for this reagent.

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References: 2 entries

Lam et al. 2015. MAbs. 7(6):1178-94. PMID: 26305993.

A potent neutralizing IgM mAb targeting the N218 epitope on E2 protein protects against Chikungunya virus pathogenesis.

Europe PMC ID: 26305993


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References: 2 entries

Lam et al. 2015. MAbs. 7(6):1178-94. PMID: 26305993.

A potent neutralizing IgM mAb targeting the N218 epitope on E2 protein protects against Chikungunya virus pathogenesis.


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