CDK inhibitor BS-194 Small Molecule (Tool Compound)
Invented at Imperial College
- Datasheet
- References (2)
- Inventor Info
Info
| Catalogue Number | 153191 |
| Type | Inhibitor |
| Relevance | BS-194 is a selective and potent CDK inhibitor, which inhibits CDK2, CDK1, CDK5, CDK7, and CDK9. |
| On Target IC50 | CDK2, CDK1, CDK5, CDK7, and CDK9 (IC50=3, 30, 30, 250, and 90 nmol/L, respectively) |
| Selectivity | CDK1, CDK2, CDK7, and CDK9 |
| Molecular Formula | C20H27N5O3 |
| lUPAC | (2S,3S)-3-(7-(benzylamino)-3- isopropylpyrazolo[1,5-a]pyrimidin-5- ylamino)butane-1,2,4-triol |
| Molecular Weight (g/mol) | 385.5 |
| Research Area | Cancer, Cell Cycle |
| Storage | Ambient |
References: 2 entries
Heathcote et al. 2010. J Med Chem. 53(24):8508-22. PMID: 21080703.
A novel pyrazolo[1,5-a]pyrimidine is a potent inhibitor of cyclin-dependent protein kinases 1, 2, and 9, which demonstrates antitumor effects in human tumor xenografts following oral administration.
Europe PMC ID: 21080703
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References: 2 entries
Heathcote et al. 2010. J Med Chem. 53(24):8508-22. PMID: 21080703.
A novel pyrazolo[1,5-a]pyrimidine is a potent inhibitor of cyclin-dependent protein kinases 1, 2, and 9, which demonstrates antitumor effects in human tumor xenografts following oral administration.
Add a reference
