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Anti-Phospho-Rb (Thr356) [7F10]

Invented by Prof Sibylle Mittnacht at University College London

Info

Catalogue Number 153190
Applications IHC WB
Antigen/Gene or Protein Targets Rb (phospho Thr356)
Synonyms Retinoblastoma 1; RB1; p105-Rb; RB; pp110; pRb; OSRC
Reactivity Human and Mouse
Relevance Rb is a tumor suppressor nuclear phosphoprotein capable of binding to DNA. It is phosphorylated on serine and threonine, but not on tyrosine residues. It forms a complex with SV40 large T antigen, adenovirus E1A, and human papilloma virus-16 E. Rb protein may act by regulating transcription and loss of its function leads to uncontrolled cell growth. Aberrations in the RB gene have been implicated in cancers of breast, colon, prostate, kidney, nasopharynx, and leukemia. Phosphorylation of Rb at S608 depends on CDK4.
Host Rat
Immunogen Synthetic peptide COOH-C-ERERpTPRKNN-NH2 coupled to mycobacterium tuberculosis PPD
Subclass IgG2a
Molecular Weight (kDa) 111
Research Area Cancer, Cell Cycle, Cell Signaling & Signal Transduction, Gene Expression, Stem Cell Biology

References

There are 2 reference entries for this reagent.

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References: 2 entries

Barrie et al. 2003. Anal Biochem. 320(1):66-74. PMID: 12895470.

High-throughput screening for the identification of small-molecule inhibitors of retinoblastoma protein phosphorylation in cells.

Europe PMC ID: 12895470


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References: 2 entries

Barrie et al. 2003. Anal Biochem. 320(1):66-74. PMID: 12895470.

High-throughput screening for the identification of small-molecule inhibitors of retinoblastoma protein phosphorylation in cells.


Add a reference

Inventor Information