Anti-ZIC2, Polyclonal [ZIC2]
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Info
| Applications | ELISA WB |
| Antigen/Gene or Protein Targets | ZIC2 |
| Reactivity | Human and Mouse |
| Relevance | Acts as a transcriptional activator or repressor. Plays important roles in the early stage of organogenesis of the CNS. Activates the transcription of the serotonin transporter SERT in uncrossed ipsilateral retinal ganglion cells (iRGCs) to refine eyespecific projections in primary visual targets. Its transcriptional activity is repressed by MDFIC. Involved in the formation of the ipsilateral retinal projection at the optic chiasm midline. Drives the expression of EPHB1 on ipsilaterally projecting growth cones. Binds to the minimal GLIconsensus sequence 5'TGGGTGGTC3'. Associates to the basal SERT promoter region from ventrotemporal retinal segments of retinal embryos |
| Host | Rabbit |
| Immunogen | 3 synthetic peptides (human) conjugated to KLH |
| Formulation | 0.5 X PBS, containing a final concentration of 50% Glycerol, 0.1% BSA and 0.01% Thimerosal. |
| Method of Purification | Immunogen affinity purification |
| Molecular Weight (kDa) | 55 |
| Research Area | Epigenetics & Nuclear Signalling, Neurobiology |
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