Cancer Research Technology
Log in Register
Menu

Anti-CLOCK, Polyclonal [CLOCK]

Info

Applications ELISA IF WB
Antigen/Gene or Protein Targets CLOCK
Reactivity Human and Mouse
Relevance ARNTL/2­CLOCK heterodimers activate E­box element (3'­CACGTG­5') transcription of a number of proteins of the circadian clock. Activates transcription of PER1 and PER2. This transcription is inhibited in a feedback loop by PER and CRY proteins. Has intrinsic histone acetyltransferase activity and this enzymatic function contributes to chromatin­remodeling events implicated in circadian control of gene expression . Acetylates primarily histones H3 and H4. Acetylates also a non­histone substrate: ARNTL. This gene encodes a protein that belongs to the basic helix­loop­helix (bHLH) family of transcription factors. Polymorphisms within the encoded protein have been associated with circadian rhythm sleep disorders. A similar protein in mice is a circadian regulator that acts as a transcription factor and forms a heterodimer with aryl hydrocarbon receptor nuclear translocator­like to activate transcription of mouse period 1. [provided by RefSeq, Jul 2008]
Host Rabbit
Immunogen 3 synthetic peptides (human) conjugated to KLH
Formulation 0.5 X PBS, containing a final concentration of 50% Glycerol, 0.1% BSA and 0.01% Thimerosal.
Method of Purification Immunogen affinity purification
Molecular Weight (kDa) 95.3
Research Area Cancer, Cardiovascular, Epigenetics & Nuclear Signalling, Metabolism, Neurobiology

References

There are 0 reference entries for this reagent.

References: 0 entry

There is no reference for this reagent yet, feel free to use the button below to suggest one.

Add a reference

References: 0 entry

There is no reference for this reagent yet, feel free to use the button below to suggest one.

Add a reference

Inventor Information

No inventors are currently linked to this reagent.

Add an inventor