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Monoclonal Antibodies

Anti-MTBP [2C1G6]

Invented at University of Liverpool
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Western blot analysis using H1299 and MCF7 lysates. 7.5% gel, 25ug/well. Antibodies were used at 3ug/ml.
Western blot analysis comparing binding to murine and human MTBP. 30ug H1299 protein/well. Mouse antibodies were at a concentration of 3ug/ml. AS-1 rabbit 1:1000.
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Catalogue Number 152835
Applications WB
Antigen/Gene or Protein Targets MTBP
Synonyms MDM2 Binding Protein, MDM2 (Mouse Double Minute 2)-Binding Protein, Mdm2, Transformed 3T3 Cell Double Minute 2, P53 Binding Protein (Mouse) Binding Protein, Mdm2, Transformed 3T3 Cell Double Minute 2, P53 Binding Protein Binding Protein, MDM2BP,
HMTBP
Reactivity Human and Mouse
Relevance MTBP is an MDM2 binding protein that alters p53/MDM2 homeostasis and may contribute to metastatic suppression. Recent studies have demonstrated that loss of MTBP expression in samples that are p53 positive and have low MDM2 is significantly associated with reduced patient survival in Squamous cell carcinoma of the head and neck (SCCHN).
Host Mouse
Immunogen Recombinant full-length human MTBP
Notes Clone also known as 15 or T15.
Research Area Cancer, Cell Cycle, Epigenetics & Nuclear Signalling

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Invented at

University of Liverpool
University of Liverpool

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