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Anti-MTBP [2C1G6]
Invented at University of Liverpool
Anti-MTBP [2C1E11]
Invented at University of Liverpool
- Datasheet
- References (2)
- Inventor Info
Info
| Catalogue Number | 151708 |
| Applications | WB |
| Antigen/Gene or Protein Targets | MTBP |
| Synonyms |
MDM2 Binding Protein, MDM2 (Mouse Double Minute 2)-Binding Protein, Mdm2, Transformed 3T3 Cell Double Minute 2, P53 Binding Protein (Mouse) Binding Protein, Mdm2, Transformed 3T3 Cell Double Minute 2, P53 Binding Protein Binding Protein, MDM2BP, HMTBP |
| Reactivity | Human |
| Relevance | MTBP is an MDM2 binding protein that alters p53/MDM2 homeostasis and may contribute to metastatic suppression. Recent studies have demonstrated that loss of MTBP expression in samples that are p53 positive and have low MDM2 is significantly associated with reduced patient survival in Squamous cell carcinoma of the head and neck (SCCHN). |
| Host | Mouse |
| Immunogen | Recombinant full-length human MTBP |
| Subclass | IgG1 kappa |
| Notes | Clone also known as 14 or T14. |
| Research Area | Cancer, Cell Cycle, Epigenetics & Nuclear Signalling |
References: 2 entries
Vlatković et al. 2011. Cancer. 117(13):2939-50. PMID: 21692053.
Loss of MTBP expression is associated with reduced survival in a biomarker-defined subset of patients with squamous cell carcinoma of the head and neck.
Europe PMC ID: 21692053
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References: 2 entries
Vlatković et al. 2011. Cancer. 117(13):2939-50. PMID: 21692053.
Loss of MTBP expression is associated with reduced survival in a biomarker-defined subset of patients with squamous cell carcinoma of the head and neck.
Add a reference
