- Reviews (0)
|Applications||ELISA IHC WB|
|Antigen/Gene or Protein Targets||Programmed Cell Death 1 Ligand 2 (PDL2-Soluble form)|
|Synonyms||B7 dendritic cell molecule, B7-DC, B7DC, bA574F11.2, Btdc, Butyrophilin B7 DC, Butyrophilin B7-DC, Butyrophilin B7DC, CD 273, CD273, CD273 antigen, MGC142238, MGC142240, PD 1 ligand 2, PD L2, PD-1 ligand 2, PD-L2, PD1 ligand 2, PD1L2_HUMAN, PDCD 1 ligand 2, PDCD1 ligand 2|
PDL2 is involved in the costimulatory signal, essential for T-cell proliferation and IFNG production in a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation by blocking cell cycle progression and cytokine production.
PD-1, is a key immune checkpoint. Currently several anti-PD-1 antibodies or blockers are in cancer clinical trials and showing promising outcomes. This antibody will allow scientists examine, for the first time, the clinical significance of PDL2-secreted form.
|Immunogen||Ovalbumin-conjugated synthetic peptide KAVFFKRHN|
|Positive Control||IHC: formalin-fixed, paraffin-embedded multi tumour tissue microarray|
|Notes||For IHC perform antigen retrieval step: microwave 20 min @ 800W in 10 mM citrate buffer, pH 6.0|
Have you used this reagent? Share your experience by submitting a review and help your fellow scientists.Review this reagent