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Monoclonal Antibodies

Anti-PDL2 (soluble form) [Z64P2D3*H4]
RECENTLY UPDATED

Invented by Ayham Alnabulsi from Vertebrate Antibodies Limited
Invented at Vertebrate Antibodies Limited
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Immunohistochemistry was performed on formalin-fixed, paraffin-embedded human testis seminoma tissue sections using anti-PDL2 (soluble form) [Z64P2D3*H4]. Cytoplasmic staining was observed.
Western blotting was performed on Jurkat cell lysates using anti-PDL2 (soluble form) [Z64P2D3*H4]. Protein of the expected size were detected.
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Catalogue Number 152795
Applications ELISA IHC WB
Antigen/Gene or Protein Targets Programmed Cell Death 1 Ligand 2 (PDL2-Soluble form)
Synonyms B7 dendritic cell molecule, B7-DC, B7DC, bA574F11.2, Btdc, Butyrophilin B7 DC, Butyrophilin B7-DC, Butyrophilin B7DC, CD 273, CD273, CD273 antigen, MGC142238, MGC142240, PD 1 ligand 2, PD L2, PD-1 ligand 2, PD-L2, PD1 ligand 2, PD1L2_HUMAN, PDCD 1 ligand 2, PDCD1 ligand 2
Reactivity Human
Relevance Monoclonal antibody which can aid understanding of programmed death ligand 2, in the secreted form.

Background and Research Application
PDL2 is involved in the costimulatory signal, essential for T-cell proliferation and IFNG production in a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation by blocking cell cycle progression and cytokine production.). PDL2 is an immune checkpoint receptor ligand which plays a role in negative regulation of the adaptive immune response.PD-L2 is one of two known ligands for Programmed cell death protein 1 (PD-1).

PD-1, is a key immune checkpoint. Currently several anti-PD-1 antibodies or blockers are in cancer clinical trials and showing promising outcomes. This antibody will allow scientists examine, for the first time, the clinical significance of PDL2-secreted form.
Host Mouse
Immunogen Ovalbumin-conjugated synthetic peptide KAVFFKRHN
Immunogen UniProt ID Q9BQ51
Positive Control IHC: formalin-fixed, paraffin-embedded multi tumour tissue microarray
Subclass Not Known
Myeloma Used P3X63Ag8.653
Strain Balb/c
Notes Production Details
Purified using multi-step affinity chromatography with protein A.

Storage Conditions
Store at -20 degrees frozen. Avoid repeated freeze/thaw cycles.

Points of Interest
For IHC perform antigen retrieval step: microwave 20 min @ 800W in 10 mM citrate buffer, pH 6.0.

Concentration
1mg/ml as standard
Research Area Immunology

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