Anti-PDL2 (soluble form) [Z64P2D3*H4]
Invented by Ayham Alnabulsi at Vertebrate Antibodies Limited
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![Immunohistochemistry was performed on formalin-fixed, paraffin-embedded human testis seminoma tissue sections using anti-PDL2 (soluble form) [Z64P2D3*H4]. Cytoplasmic staining was observed.](https://res.cloudinary.com/ximbio/image/upload/c_fit/1fd95695-faff-4626-a2cf-2a4d07b8b7d5.jpg)
![Western blotting was performed on Jurkat cell lysates using anti-PDL2 (soluble form) [Z64P2D3*H4]. Protein of the expected size were detected.](https://res.cloudinary.com/ximbio/image/upload/c_fit/53703bf4-55ba-475c-81c7-514110fdf767.png)
![Immunohistochemistry was performed on formalin-fixed, paraffin-embedded human testis seminoma tissue sections using anti-PDL2 (soluble form) [Z64P2D3*H4]. Cytoplasmic staining was observed.](https://res.cloudinary.com/ximbio/image/upload/c_limit,h_282,w_368/1fd95695-faff-4626-a2cf-2a4d07b8b7d5.jpg)
![Western blotting was performed on Jurkat cell lysates using anti-PDL2 (soluble form) [Z64P2D3*H4]. Protein of the expected size were detected.](https://res.cloudinary.com/ximbio/image/upload/c_limit,h_282,w_368/53703bf4-55ba-475c-81c7-514110fdf767.png)
![Image thumbnail for Anti-PDL2 (soluble form) [Z64P2D3*H4]](https://res.cloudinary.com/ximbio/image/upload/c_fit,h_45/1fd95695-faff-4626-a2cf-2a4d07b8b7d5.jpg)
![Image thumbnail for Anti-PDL2 (soluble form) [Z64P2D3*H4]](https://res.cloudinary.com/ximbio/image/upload/c_fit,h_45/53703bf4-55ba-475c-81c7-514110fdf767.png)
| Catalogue Number | 152795 |
| Applications | ELISA IHC WB |
| Antigen/Gene or Protein Targets | Programmed Cell Death 1 Ligand 2 (PDL2-Soluble form) |
| Synonyms | B7 dendritic cell molecule, B7-DC, B7DC, bA574F11.2, Btdc, Butyrophilin B7 DC, Butyrophilin B7-DC, Butyrophilin B7DC, CD 273, CD273, CD273 antigen, MGC142238, MGC142240, PD 1 ligand 2, PD L2, PD-1 ligand 2, PD-L2, PD1 ligand 2, PD1L2_HUMAN, PDCD 1 ligand 2, PDCD1 ligand 2 |
| Reactivity | Human |
| Relevance |
PDL2 is involved in the costimulatory signal, essential for T-cell proliferation and IFNG production in a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation by blocking cell cycle progression and cytokine production. PD-1, is a key immune checkpoint. Currently several anti-PD-1 antibodies or blockers are in cancer clinical trials and showing promising outcomes. This antibody will allow scientists examine, for the first time, the clinical significance of PDL2-secreted form. |
| Host | Mouse |
| Immunogen | Ovalbumin-conjugated synthetic peptide KAVFFKRHN |
| Subclass | Not Known |
| Positive Control | IHC: formalin-fixed, paraffin-embedded multi tumour tissue microarray |
| Myeloma Used | P3X63Ag8.653 |
| Strain | Balb/c |
| Notes | For IHC perform antigen retrieval step: microwave 20 min @ 800W in 10 mM citrate buffer, pH 6.0 |
| Research Area | Immunology |
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