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Anti-PDL2 (soluble form) [Z64P2D3*H4]

Invented by Ayham Alnabulsi at Vertebrate Antibodies Limited

Info

Catalogue Number 152795
Applications ELISA IHC WB
Antigen/Gene or Protein Targets Programmed Cell Death 1 Ligand 2 (PDL2-Soluble form)
Synonyms B7 dendritic cell molecule, B7-DC, B7DC, bA574F11.2, Btdc, Butyrophilin B7 DC, Butyrophilin B7-DC, Butyrophilin B7DC, CD 273, CD273, CD273 antigen, MGC142238, MGC142240, PD 1 ligand 2, PD L2, PD-1 ligand 2, PD-L2, PD1 ligand 2, PD1L2_HUMAN, PDCD 1 ligand 2, PDCD1 ligand 2
Reactivity Human
Relevance PDL2 is involved in the costimulatory signal, essential for T-cell proliferation and IFNG production in a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation by blocking cell cycle progression and cytokine production.

PD-1, is a key immune checkpoint. Currently several anti-PD-1 antibodies or blockers are in cancer clinical trials and showing promising outcomes. This antibody will allow scientists examine, for the first time, the clinical significance of PDL2-secreted form.
Host Mouse
Immunogen Ovalbumin-conjugated synthetic peptide KAVFFKRHN
Subclass Not Known
Positive Control IHC: formalin-fixed, paraffin-embedded multi tumour tissue microarray
Myeloma Used P3X63Ag8.653
Strain Balb/c
Notes For IHC perform antigen retrieval step: microwave 20 min @ 800W in 10 mM citrate buffer, pH 6.0
Research Area Immunology

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