Catalogue Number
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152795 |
Applications
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ELISA
IHC
WB
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Antigen/Gene or Protein Targets
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Programmed Cell Death 1 Ligand 2 (PDL2-Soluble form)
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Synonyms
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B7 dendritic cell molecule, B7-DC, B7DC, bA574F11.2, Btdc, Butyrophilin B7 DC, Butyrophilin B7-DC, Butyrophilin B7DC, CD 273, CD273, CD273 antigen, MGC142238, MGC142240, PD 1 ligand 2, PD L2, PD-1 ligand 2, PD-L2, PD1 ligand 2, PD1L2_HUMAN, PDCD 1 ligand 2, PDCD1 ligand 2
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Reactivity
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Human
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Relevance
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Monoclonal antibody which can aid understanding of programmed death ligand 2, in the secreted form.
Background and Research Application
PDL2 is involved in the costimulatory signal, essential for T-cell proliferation and IFNG production in a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation by blocking cell cycle progression and cytokine production.). PDL2 is an immune checkpoint receptor ligand which plays a role in negative regulation of the adaptive immune response.PD-L2 is one of two known ligands for Programmed cell death protein 1 (PD-1).
PD-1, is a key immune checkpoint. Currently several anti-PD-1 antibodies or blockers are in cancer clinical trials and showing promising outcomes. This antibody will allow scientists examine, for the first time, the clinical significance of PDL2-secreted form.
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Host
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Mouse
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Immunogen
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Ovalbumin-conjugated synthetic peptide KAVFFKRHN
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Immunogen UniProt ID
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Q9BQ51
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Positive Control
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IHC: formalin-fixed, paraffin-embedded multi tumour tissue microarray
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Subclass
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Not Known
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Myeloma Used
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P3X63Ag8.653
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Strain
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Balb/c
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Notes
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Production Details
Purified using multi-step affinity chromatography with protein A.
Storage Conditions
Store at -20 degrees frozen. Avoid repeated freeze/thaw cycles.
Points of Interest
For IHC perform antigen retrieval step: microwave 20 min @ 800W in 10 mM citrate buffer, pH 6.0.
Concentration
1mg/ml as standard
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Research Area
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Immunology
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