Cancer Research Technology
Log in Register
Menu

Mapt-9A18 phosphodefective Tau Mouse

Invented by Prof Michael Coleman at Babraham Institute

Info

Catalogue Number 152794
Antigen/Gene or Protein Targets Microtubule-associated protein Tau
Disease Keywords Dementia; Alzheimer's disease and other tauopathies; Tauopathy;
Synonyms MAPT, Neurofibrillary tangle protein, paired helical filament-tau, PHF-tau
Model Knock-In
Relevance Hyperphosphorylation and fibrillar aggregation of the microtubule-associated protein tau are key features of Alzheimer's disease and other tauopathies. Tauopathies are characterized by aggregation of microtubule-associated protein tau into neurofibrillary tangles (NFTs). The Mapt-9A18 phosphodefective tau knockin mouse expresses phosphodefective tau with 18 alanine substitutions at serine and/or threonine residues in the proline-rich and first microtubule-binding domains to model hyperphosphorylation.

This is a matched counterpart mouse model for the Mapt9E18 phosphomimetic tau knockin mouse which has 18 glutamate substitutions as a model of an inherited taupathy; frontotemporal dementia with parkinsonism linked to tau mutations on chromosome 17 (FTDP-17T).
Conditional No
Strain C57BL/6
Research Area Cell Structure and Motility, Genetic Studies Tools, Neurobiology

References

There are 2 reference entries for this reagent.

View All References

References: 2 entries

Gilley et al. 2016. Neurobiol Aging. 39:1-18. PMID: 26923397.

Mislocalization of neuronal tau in the absence of tangle pathology in phosphomutant tau knockin mice.

Europe PMC ID: 26923397


Add a reference

References: 2 entries

Gilley et al. 2016. Neurobiol Aging. 39:1-18. PMID: 26923397.

Mislocalization of neuronal tau in the absence of tangle pathology in phosphomutant tau knockin mice.


Add a reference