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- Inventor Info
|Antigen/Gene or Protein Targets||Microtubule-associated protein Tau|
|Disease Keywords||Dementia; Alzheimer's disease and other tauopathies; Tauopathy;|
|Synonyms||MAPT, Neurofibrillary tangle protein, paired helical filament-tau, PHF-tau|
Hyperphosphorylation and fibrillar aggregation of the microtubule-associated protein tau are key features of Alzheimer's disease and other tauopathies. Tauopathies are characterized by aggregation of microtubule-associated protein tau into neurofibrillary tangles (NFTs). The Mapt-9A18 phosphodefective tau knockin mouse expresses phosphodefective tau with 18 alanine substitutions at serine and/or threonine residues in the proline-rich and first microtubule-binding domains to model hyperphosphorylation.
This is a matched counterpart mouse model for the Mapt9E18 phosphomimetic tau knockin mouse which has 18 glutamate substitutions as a model of an inherited taupathy; frontotemporal dementia with parkinsonism linked to tau mutations on chromosome 17 (FTDP-17T).
|Research Area||Cell Structure and Motility, Genetic Studies Tools, Neurobiology|
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