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- Inventor Info
|Antigen/Gene or Protein Targets||Microtubule-associated protein Tau|
|Disease Keywords||Alzheimer's disease, tauopathies, parkinsonism|
|Synonyms||MAPT, Neurofibrillary tangle protein, paired helical filament-tau, PHF-tau|
Hyperphosphorylation and fibrillar aggregation of the microtubule-associated protein tau (MAPT) are key features of Alzheimer's disease and other tauopathies. Tauopathies are characterized by aggregation of microtubule-associated protein tau into neurofibrillary tangles (NFTs).
The Mapt-9E18 phosphomimetic tau knockin mouse expresses phosphomimetic tau with 18 glutamate substitutions at serine and/or threonine residues in the proline-rich and first microtubule-binding domains to model hyperphosphorylation. This is a model of frontotemporal dementia with parkinsonism linked to tau mutations on chromosome 17 (FTDP-17T). There is a complementary phosphodefective counterpart mouse that has matched alanine substitutions (Mapt-9A18).
|Research Area||Cell Structure and Motility, Genetic Studies Tools, Neurobiology|
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