| Catalogue Number | 152784 |
| Antigen/Gene or Protein Targets | Microtubule-associated protein Tau |
| Disease Keywords | Alzheimer's disease, tauopathies, parkinsonism |
| Synonyms | MAPT, Neurofibrillary tangle protein, paired helical filament-tau, PHF-tau |
| Model | Knock-In |
| Relevance |
Hyperphosphorylation and fibrillar aggregation of the microtubule-associated protein tau (MAPT) are key features of Alzheimer's disease and other tauopathies. Tauopathies are characterized by aggregation of microtubule-associated protein tau into neurofibrillary tangles (NFTs). The Mapt-9E18 phosphomimetic tau knockin mouse expresses phosphomimetic tau with 18 glutamate substitutions at serine and/or threonine residues in the proline-rich and first microtubule-binding domains to model hyperphosphorylation. This is a model of frontotemporal dementia with parkinsonism linked to tau mutations on chromosome 17 (FTDP-17T). There is a complementary phosphodefective counterpart mouse that has matched alanine substitutions (Mapt-9A18). |
| Conditional | No |
| Strain | C57BL/6 |
| Research Area | Cell Structure and Motility, Genetic Studies Tools, Neurobiology |
Gilley et al. 2016. Neurobiol Aging. 39:1-18. PMID: 26923397.
Mislocalization of neuronal tau in the absence of tangle pathology in phosphomutant tau knockin mice.
Europe PMC ID: 26923397
Gilley et al. 2016. Neurobiol Aging. 39:1-18. PMID: 26923397.
Mislocalization of neuronal tau in the absence of tangle pathology in phosphomutant tau knockin mice.
