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Mapt-9E18 phosphomimetic Tau Mouse

Invented by Prof Michael Coleman at Babraham Institute

Info

Catalogue Number 152784
Antigen/Gene or Protein Targets Microtubule-associated protein Tau
Disease Keywords Alzheimer's disease, tauopathies, parkinsonism
Synonyms MAPT, Neurofibrillary tangle protein, paired helical filament-tau, PHF-tau
Model Knock-In
Relevance Hyperphosphorylation and fibrillar aggregation of the microtubule-associated protein tau (MAPT) are key features of Alzheimer's disease and other tauopathies. Tauopathies are characterized by aggregation of microtubule-associated protein tau into neurofibrillary tangles (NFTs).

The Mapt-9E18 phosphomimetic tau knockin mouse expresses phosphomimetic tau with 18 glutamate substitutions at serine and/or threonine residues in the proline-rich and first microtubule-binding domains to model hyperphosphorylation. This is a model of frontotemporal dementia with parkinsonism linked to tau mutations on chromosome 17 (FTDP-17T). There is a complementary phosphodefective counterpart mouse that has matched alanine substitutions (Mapt-9A18).
Conditional No
Strain C57BL/6
Research Area Cell Structure and Motility, Genetic Studies Tools, Neurobiology

References

There are 2 reference entries for this reagent.

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References: 2 entries

Gilley et al. 2016. Neurobiol Aging. 39:1-18. PMID: 26923397.

Mislocalization of neuronal tau in the absence of tangle pathology in phosphomutant tau knockin mice.

Europe PMC ID: 26923397


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References: 2 entries

Gilley et al. 2016. Neurobiol Aging. 39:1-18. PMID: 26923397.

Mislocalization of neuronal tau in the absence of tangle pathology in phosphomutant tau knockin mice.


Add a reference