Anti-P15PAF [K11-P1G7*B8]
Invented by Ayham Alnabulsi from Vertebrate Antibodies Limited
Invented at Vertebrate Antibodies Limited
- Datasheet
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- Inventor Info
Info
![Image thumbnail for Anti-P15PAF [K11-P1G7*B8]](https://res.cloudinary.com/ximbio/image/upload/c_fit,fl_lossy,h_45,q_auto/633ea30d-069a-4c18-b55c-5fb1d422aa7a.jpg)
| Catalogue Number | 152728 |
| Applications | ELISA IHC WB |
| Antigen/Gene or Protein Targets | PCNA-Associated Factor of 15 (PAF15) |
| Reactivity | Human |
| Relevance | Proliferating cell nuclear antigen (PCNA)-Associated Factor (PAF15) is a small protein containing a PCNA interacting motif and sequences for association with ubiquitin enzymes. In interaction with PCNA, PAF15 plays a key role in recruiting DNA replicative polymerase by double monoubiquitination at Lys(15) and Lys(24). Under DNA damage conditions, PAF15 regulates the switch from DNA replicative polymerase to translesion synthesis polymerase in order to bypass the replication-blocking lesions. Overexpression of PAF15 promotes the repair of ultraviolet-induced DNA damage and prevents cell death, whereas attenuation of PAF15 decreases DNA replication and cell survival. |
| Host | Mouse |
| Immunogen | Peptide Sequence – RKACPLQPDHT -peptide immunogen is identical in mouse (Mus musculus) and rat (Rattus norvegicus). |
| Positive Control | ELISA - peptide immunogen; WB - Jurkat whole cell lysate; IHC - formalin-fixed, paraffin-embedded multi tumour tissue microarray |
| Subclass | IgG2b kappa |
| Myeloma Used | P3X63Ag8.653 |
| Strain | Balb/c |
| Research Area | Apoptosis and Programmed Cell Death, Cancer, Cell Cycle, Metabolism |
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