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Anti-P15PAF [K11-P1G7*B8]

Invented by Ayham Alnabulsi at Vertebrate Antibodies Limited

Info

Catalogue Number 152728
Applications ELISA IHC WB
Antigen/Gene or Protein Targets PCNA-Associated Factor of 15 (PAF15)
Reactivity Human
Relevance Proliferating cell nuclear antigen (PCNA)-Associated Factor (PAF15) is a small protein containing a PCNA interacting motif and sequences for association with ubiquitin enzymes. In interaction with PCNA, PAF15 plays a key role in recruiting DNA replicative polymerase by double monoubiquitination at Lys(15) and Lys(24). Under DNA damage conditions, PAF15 regulates the switch from DNA replicative polymerase to translesion synthesis polymerase in order to bypass the replication-blocking lesions. Overexpression of PAF15 promotes the repair of ultraviolet-induced DNA damage and prevents cell death, whereas attenuation of PAF15 decreases DNA replication and cell survival.
Host Mouse
Immunogen Peptide Sequence – RKACPLQPDHT -peptide immunogen is identical in mouse (Mus musculus) and rat (Rattus norvegicus).
Positive Control ELISA - peptide immunogen; WB - Jurkat whole cell lysate; IHC - formalin-fixed, paraffin-embedded multi tumour tissue microarray
Subclass IgG2b kappa
Myeloma Used P3X63Ag8.653
Strain Balb/c
Research Area Apoptosis and Programmed Cell Death, Cancer, Cell Cycle, Metabolism

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