- References (2)
- Inventor Info
|Applications||ELISA IHC WB|
|Antigen/Gene or Protein Targets||Cytochrome P450, Family 1, Subfamily B, Polypeptide 1, CYP1B1|
|Reactivity||Human, Mouse and Rat|
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.Participates in the metabolism of an as-yet-unknown biologically active molecule that is a participant in eye development.
CYP1B1 is upregulated in tumour cells and is a therapeutic target
|Immunogen||Ovalbumin-conjugated synthetic peptide - PENFDPARFLDKDGL|
|Positive Control||IHC: formalin-fixed, paraffin-embedded ovarian cancer sections; Western Blot: Recombinant human CYP1B1 expressed in lymphoblast microsomes|
|Molecular Weight (kDa)||52|
Does not react with CYP1A1.
ELISA pair with anti-CYP1B1, clone 5E2.
By IHC this antibody detected detected CYP1B1 in biopsy samples of cancers of the bladder, brain, breast, colon, connective tissue, esophagus, kidney, lung, lymph node, ovary, skin, stomach, testis and uterus, but not normal cells.
|Research Area||Cancer, Cardiovascular, Cell Signaling & Signal Transduction, Metabolism|
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