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Anti-VTN2 [1A5]

Info

Catalogue Number 152667
Applications IF WB
Antigen/Gene or Protein Targets Splice variant of Zebrafish IKKg protein (154 amino acids)
Reactivity Human and Zebrafish
Relevance NF-κB (nuclear factor kappaB) is a transcription factor that activates numerous target genes important in mediating innate and adaptive immunity in mammals. Activation by external stimuli such as TNF leads to the activation of kinases (IKK1 and IKK2) that phosphorylate inhibitory proteins I-κB and their subsequent degradation. IKK1 and IKK2 form the catalytic subunits of a complex which includes IKKγ, the regulatory component (also known as NEMO). Mutations in NEMO are the cause of the human disorders incontinentia pigmenti and ectodermal dysplasia (ED-AID).
Host Mouse
Immunogen GST/His-tagged splice variant of Zebrafish IKKγ protein of 154 amino acids fusion protein
Positive Control Zebrafish embryos, HEK293 cells
Subclass IgG1
Myeloma Used Sp2/0-Ag14
Research Area Aquaculture, Epigenetics & Nuclear Signalling, Protein Degradation

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