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Anti-ORF7a [3C9]

Info

Catalogue Number 152647
Applications IF WB
Antigen/Gene or Protein Targets SARS CoV ORF7a (also known as U122)
Reactivity Virus
Relevance A novel coronavirus (termed as SARS-CoV) has been identified as the etiological agent of severe acute respiratory syndrome (SARS). The SARS-CoV genome encodes the essential CoV replication and structural proteins. In addition, the genome encodes eight 8 putative accessory proteins (i.e. ORFs 3a, 3b, 6, 7a, 7b, 8a, 8b and 9b) that do not show significant homology to viral proteins of known coronaviruses, i.e. they are unique to SARS-CoV. ORF7a, which is also known as U122, consists of 122 amino acids and is localized mainly in ER-Golgi intermediate compartment, where coronaviruses are known to assemble and bud. Interestingly, ORF7a can also be incorporated into the virion. The over-expression of ORF7a induces apoptosis and block cell cycle progression at G0/G1 phase. Another study showed that the over-expression of ORF7a inhibited cellular protein synthesis and induced the phosphorylation and activation of p38 mitogen activated protein kinase (MAPK).
Host Mouse
Immunogen GST-7a (16-111 amino acids)
Subclass IgG1
Molecular Weight (kDa) 14
Myeloma Used Sp2/0-Ag14
Research Area Cell Signaling & Signal Transduction, Neurobiology

References: 1 entry

Tan et al. 2007. J Virol. 81(12):6346-55. PMID: 17428862.


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References: 1 entry

Tan et al. 2007. J Virol. 81(12):6346-55. PMID: 17428862.


Add a reference

References: 1 entry

Tan et al. 2007. J Virol. 81(12):6346-55. PMID: 17428862.


Add a reference


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