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|Antigen/Gene or Protein Targets||Liver-enriched gene 1 (previously called D12)|
Leg1 is a novel protein of 361 amino acids. Preliminary data suggested that Leg1 (previously named as D12) is involved in early liver development. However, no detailed characterization of Leg1 has been reported thus far.
There are two copies of leg1 in zebrafish, namely leg1a and leg1b. Both leg1a and leg1b are expressed in the larvae and adult liver with leg1a being the predominant form. Knockdown of Leg1a or Leg1b by their respective morpholinos specifically targeting their 59-UTR each resulted in a small liver phenotype, demonstrating that both Leg1a and Leg1b are important for early liver development.
|Immunogen||GST-Leg 1 fusion protein|
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