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Anti-BF-1 [3C6]

Info

Catalogue Number 152636
Applications IF WB
Antigen/Gene or Protein Targets BF-1
Reactivity Human
Relevance Apoptosis in host cells during infection is thought to serve as a defense mechanism for the removal of the infectious agents. Pathogenic bacteria could be broadly classified as invasive or non-invasive. Certain invasive pathogens have been reported to inhibit apoptosis in the host cells so as to persist, multiply and avoid components of the circulating immune system. Mechanistic analysis of this process not only would help to understand the infectious process, but it would certainly provide important clues to help understand the composition of the fundamental machineries and mechanisms of the apoptosis regulation in mammalian cells. In this regard, studies have been focusing on the identification of the bacterial factor(s) that might be involved in the inhibition of apoptosis signaling of host cells during infection. One factor identified, termed BF-1, appear to be capable of inhibiting apoptosis in infected epithelial cells. Furthermore, mammalian epithelial cells expressing this factor were rendered resistant to apoptosis mediated by several apoptotic stimuli (unpublished data).
Host Mouse
Immunogen GST-BF-1 fusion protein
Subclass IgG1
Myeloma Used Sp2/0-Ag14
Research Area Apoptosis and Programmed Cell Death, Bacteriology, Cell Signaling & Signal Transduction

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