#152636

Anti-BF-1 [3C6]

Cat. #152636

Anti-BF-1 [3C6]

Cat. #: 152636

Unit size: 100 ug

Availability: 3-4 weeks

Target: BF-1

Class: Monoclonal

Application: IF ; WB

Reactivity: Human

Host: Mouse

£300.00

This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.

Contributor

Institute: A*STAR Accelerate Technologies Pte Ltd

Tool Details
Target Details
Applications
Handling

Tool Details

*FOR RESEARCH USE ONLY

  • Name: Anti-BF-1 [3C6]
  • Clone: 3C6
  • Class: Monoclonal
  • Conjugation: Unconjugated
  • Reactivity: Human
  • Host: Mouse
  • Application: IF ; WB
  • Description: Apoptosis in host cells during infection is thought to serve as a defense mechanism for the removal of the infectious agents. Pathogenic bacteria could be broadly classified as invasive or non-invasive. Certain invasive pathogens have been reported to inhibit apoptosis in the host cells so as to persist, multiply and avoid components of the circulating immune system. Mechanistic analysis of this process not only would help to understand the infectious process, but it would certainly provide important clues to help understand the composition of the fundamental machineries and mechanisms of the apoptosis regulation in mammalian cells. In this regard, studies have been focusing on the identification of the bacterial factor(s) that might be involved in the inhibition of apoptosis signaling of host cells during infection. One factor identified, termed BF-1, appear to be capable of inhibiting apoptosis in infected epithelial cells. Furthermore, mammalian epithelial cells expressing this factor were rendered resistant to apoptosis mediated by several apoptotic stimuli (unpublished data).
  • Immunogen: GST-BF-1 fusion protein
  • Isotype: IgG1
  • Myeloma used: Sp2/0-Ag14

Target Details

  • Target: BF-1
  • Target background: Apoptosis in host cells during infection is thought to serve as a defense mechanism for the removal of the infectious agents. Pathogenic bacteria could be broadly classified as invasive or non-invasive. Certain invasive pathogens have been reported to inhibit apoptosis in the host cells so as to persist, multiply and avoid components of the circulating immune system. Mechanistic analysis of this process not only would help to understand the infectious process, but it would certainly provide important clues to help understand the composition of the fundamental machineries and mechanisms of the apoptosis regulation in mammalian cells. In this regard, studies have been focusing on the identification of the bacterial factor(s) that might be involved in the inhibition of apoptosis signaling of host cells during infection. One factor identified, termed BF-1, appear to be capable of inhibiting apoptosis in infected epithelial cells. Furthermore, mammalian epithelial cells expressing this factor were rendered resistant to apoptosis mediated by several apoptotic stimuli (unpublished data).

Applications

  • Application: IF ; WB

Handling

  • Format: Liquid
  • Concentration: 0.9-1.1mg/ml
  • Unit size: 100 ug
  • Storage buffer: PBS with 0.02% azide
  • Storage conditions: -15° C to -25° C
  • Shipping conditions: Shipping at 4° C