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Anti-EBV Latent Membrane Protein 1 [LMPO24]

Invented by Prof Martin Rowe at University Of Birmingham

Info

Catalogue Number 152632
Applications FACS IHC
Antigen/Gene or Protein Targets Epstein-Barr Virus, Latent Membrane Protein 1 (EBV-LMP1)
Reactivity Virus
Relevance EBV is a human herpesvirus that establishes a life-long persistence in the host. The virus infects the vast majority of the world's adult population and is well known for its association with a broad spectrum of benign and malignant diseases, including infectious mononucleosis, Burkitt's lymphoma, nasopharyngeal carcinoma, and is causally associated with lymphoid and epithelial malignancies, including post-transplant lymphoproliferative disorders, Hodgkin's disease, anaplastic nasopharyngeal carcinoma and gastric carcinomas. Latent membrane protein 1 (LMP1) of Epstein-Barr virus (EBV) is a transforming protein that affects multiple cell signalling pathways and contributes to EBV-associated oncogenesis. LMP1 can be expressed in some states of EBV latency, and significant induction of full-length LMP1 is also observed frequently during virus reactivation into the lytic cycle. LMP1 is critical for EBV-infected cell activation, adhesion and survival, and is usually expressed in the malignant cells.
Host Mouse
Immunogen Purified plasma membranes from LMP1 expressing insect cells infected with a recombinant LMP1 baculovirus
Subclass IgG1
Positive Control EBV transformed lymphoblastoid cell lines
Strain Balb/c
Notes Niedobitek et al., 1995: "The LMPO24 clone demonstrates strong and specific reactivity in immunohistochemical staining of paraffin-embedded tissues".
Research Area Adhesion, Cancer, Cell Signaling & Signal Transduction, Immunology, Virology

References: 1 entry

Niedobitek et al. 1995. Blood. 86(2):659-65. PMID: 7605996.

IHC


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References: 1 entry

Niedobitek et al. 1995. Blood. 86(2):659-65. PMID: 7605996.

IHC


Add a reference

References: 1 entry

Niedobitek et al. 1995. Blood. 86(2):659-65. PMID: 7605996.

IHC


Add a reference


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