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Monoclonal Antibodies

Anti-EBV Latent Membrane Protein 1 [CS 1-4]

Invented by Prof Martin Rowe at University Of Birmingham
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Catalogue Number 151471
Applications IHC IF IP WB
Antigen/Gene or Protein Targets Epstein-Barr Virus, Latent Membrane Protein 1 (EBV-LMP1)
Reactivity Virus
Relevance EBV is a human herpesvirus that establishes a life-long persistence in the host. The virus infects the vast majority of the world's adult population and is well known for its association with a broad spectrum of benign and malignant diseases, including infectious mononucleosis, Burkitt's lymphoma, nasopharyngeal carcinoma, and is causally associated with lymphoid and epithelial malignancies, including post-transplant lymphoproliferative disorders, Hodgkin's disease, anaplastic nasopharyngeal carcinoma and gastric carcinomas. Latent membrane protein 1 (LMP1) of Epstein-Barr virus (EBV) is a transforming protein that affects multiple cell signalling pathways and contributes to EBV-associated oncogenesis. LMP1 can be expressed in some states of EBV latency, and significant induction of full-length LMP1 is also observed frequently during virus reactivation into the lytic cycle. LMP1 is critical for EBV-infected cell activation, adhesion and survival, and is usually expressed in the malignant cells.

CS 1-4 is specific for Epstein-Barr virus infected cells expressing the latent membrane protein (LMP). This antibody is four pooled monoclonal antibodies that collectively detect LMP's encoded by each of 20 geographically distinct EBV isolates.
Host Mouse
Positive Control EBV transformed lymphoblastoid cell lines
Subclass IgG1 kappa
Molecular Weight (kDa) 57-66
Myeloma Used P3X63Ag8.653
Research Area Adhesion, Cancer, Cell Signaling & Signal Transduction, Immunology, Virology

References

There are 12 reference entries for this reagent.

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References: 12 entries

Flanagan et al. 2003. J Gen Virol. 84(Pt 7):1871-9. PMID: 12810882.

View  

Localization of the Epstein-Barr virus protein LMP 1 to exosomes.

Europe PMC ID: 12810882

View  

Nakatsuka et al. 2002. J Clin Oncol. 20(20):4255-60. PMID: 12377970.

View  

Pyothorax-associated lymphoma: a review of 106 cases.

Europe PMC ID: 12377970

View  

Xu et al. 2002. J Virol. 76(8):4080-6. PMID: 11907247.

View  

Preferential localization of the Epstein-Barr virus (EBV) oncoprotein LMP-1 to nuclei in human T cells: implications for its role in the development of EBV genome-positive T-cell lymphomas.

Europe PMC ID: 11907247

View  

Ascani et al. 1997. Ann Oncol. 8(11):1133-8. PMID: 9426333.

View  

Pyothorax-associated lymphoma: description of the first two cases detected in Italy.

Europe PMC ID: 9426333

View  

Epstein-Barr virus (EBV)-associated lymphoproliferative disease in the SCID mouse model: implications for the pathogenesis of EBV-positive lymphomas in man.

Europe PMC ID: 1845872

View  

Rowe et al. 1991. J Exp Med. 173(1):147-58. PMID: 1845872.

IF

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Rowe et al. 1987. J Gen Virol. 68 ( Pt 6):1575-86. PMID: 2438376.

View  

Monoclonal antibodies to the latent membrane protein of Epstein-Barr virus reveal heterogeneity of the protein and inducible expression in virus-transformed cells.

Europe PMC ID: 2438376

View  

Add a reference

References: 12 entries

Flanagan et al. 2003. J Gen Virol. 84(Pt 7):1871-9. PMID: 12810882.

View  

Localization of the Epstein-Barr virus protein LMP 1 to exosomes.

View  

Nakatsuka et al. 2002. J Clin Oncol. 20(20):4255-60. PMID: 12377970.

View  

Pyothorax-associated lymphoma: a review of 106 cases.

View  

Xu et al. 2002. J Virol. 76(8):4080-6. PMID: 11907247.

View  

Preferential localization of the Epstein-Barr virus (EBV) oncoprotein LMP-1 to nuclei in human T cells: implications for its role in the development of EBV genome-positive T-cell lymphomas.

View  

Ascani et al. 1997. Ann Oncol. 8(11):1133-8. PMID: 9426333.

View  

Pyothorax-associated lymphoma: description of the first two cases detected in Italy.

View  

Epstein-Barr virus (EBV)-associated lymphoproliferative disease in the SCID mouse model: implications for the pathogenesis of EBV-positive lymphomas in man.

View  

Rowe et al. 1991. J Exp Med. 173(1):147-58. PMID: 1845872.

IF

View  

Rowe et al. 1987. J Gen Virol. 68 ( Pt 6):1575-86. PMID: 2438376.

View  

Monoclonal antibodies to the latent membrane protein of Epstein-Barr virus reveal heterogeneity of the protein and inducible expression in virus-transformed cells.

View  

Add a reference

Inventor Information