Anti-EBV Latent Membrane Protein 1 [CS 1-4]
Invented by Prof Martin Rowe at University Of Birmingham
- Datasheet
- References (12)
- Inventor Info
Info
Catalogue Number | 151471 |
Applications | IHC IF IP WB |
Antigen/Gene or Protein Targets | Epstein-Barr Virus, Latent Membrane Protein 1 (EBV-LMP1) |
Reactivity | Virus |
Relevance |
EBV is a human herpesvirus that establishes a life-long persistence in the host. The virus infects the vast majority of the world's adult population and is well known for its association with a broad spectrum of benign and malignant diseases, including infectious mononucleosis, Burkitt's lymphoma, nasopharyngeal carcinoma, and is causally associated with lymphoid and epithelial malignancies, including post-transplant lymphoproliferative disorders, Hodgkin's disease, anaplastic nasopharyngeal carcinoma and gastric carcinomas. Latent membrane protein 1 (LMP1) of Epstein-Barr virus (EBV) is a transforming protein that affects multiple cell signalling pathways and contributes to EBV-associated oncogenesis. LMP1 can be expressed in some states of EBV latency, and significant induction of full-length LMP1 is also observed frequently during virus reactivation into the lytic cycle. LMP1 is critical for EBV-infected cell activation, adhesion and survival, and is usually expressed in the malignant cells. CS 1-4 is specific for Epstein-Barr virus infected cells expressing the latent membrane protein (LMP). This antibody is four pooled monoclonal antibodies that collectively detect LMP's encoded by each of 20 geographically distinct EBV isolates. |
Host | Mouse |
Positive Control | EBV transformed lymphoblastoid cell lines |
Subclass | IgG1 |
Molecular Weight (kDa) | 57-66 |
Myeloma Used | P3X63Ag8.653 |
Research Area | Adhesion, Cancer, Cell Signaling & Signal Transduction, Immunology, Virology |
References: 12 entries
Flanagan et al. 2003. J Gen Virol. 84(Pt 7):1871-9. PMID: 12810882.
Localization of the Epstein-Barr virus protein LMP 1 to exosomes.
Europe PMC ID: 12810882
Nakatsuka et al. 2002. J Clin Oncol. 20(20):4255-60. PMID: 12377970.
Pyothorax-associated lymphoma: a review of 106 cases.
Europe PMC ID: 12377970
Xu et al. 2002. J Virol. 76(8):4080-6. PMID: 11907247.
Preferential localization of the Epstein-Barr virus (EBV) oncoprotein LMP-1 to nuclei in human T cells: implications for its role in the development of EBV genome-positive T-cell lymphomas.
Europe PMC ID: 11907247
Ascani et al. 1997. Ann Oncol. 8(11):1133-8. PMID: 9426333.
Pyothorax-associated lymphoma: description of the first two cases detected in Italy.
Europe PMC ID: 9426333
Epstein-Barr virus (EBV)-associated lymphoproliferative disease in the SCID mouse model: implications for the pathogenesis of EBV-positive lymphomas in man.
Europe PMC ID: 1845872
Rowe et al. 1991. J Exp Med. 173(1):147-58. PMID: 1845872.
IF
Rowe et al. 1987. J Gen Virol. 68 ( Pt 6):1575-86. PMID: 2438376.
Monoclonal antibodies to the latent membrane protein of Epstein-Barr virus reveal heterogeneity of the protein and inducible expression in virus-transformed cells.
Europe PMC ID: 2438376
Add a reference
References: 12 entries
Flanagan et al. 2003. J Gen Virol. 84(Pt 7):1871-9. PMID: 12810882.
Localization of the Epstein-Barr virus protein LMP 1 to exosomes.
Nakatsuka et al. 2002. J Clin Oncol. 20(20):4255-60. PMID: 12377970.
Pyothorax-associated lymphoma: a review of 106 cases.
Xu et al. 2002. J Virol. 76(8):4080-6. PMID: 11907247.
Preferential localization of the Epstein-Barr virus (EBV) oncoprotein LMP-1 to nuclei in human T cells: implications for its role in the development of EBV genome-positive T-cell lymphomas.
Ascani et al. 1997. Ann Oncol. 8(11):1133-8. PMID: 9426333.
Pyothorax-associated lymphoma: description of the first two cases detected in Italy.
Epstein-Barr virus (EBV)-associated lymphoproliferative disease in the SCID mouse model: implications for the pathogenesis of EBV-positive lymphomas in man.
Rowe et al. 1991. J Exp Med. 173(1):147-58. PMID: 1845872.
IF
Rowe et al. 1987. J Gen Virol. 68 ( Pt 6):1575-86. PMID: 2438376.
Monoclonal antibodies to the latent membrane protein of Epstein-Barr virus reveal heterogeneity of the protein and inducible expression in virus-transformed cells.
Add a reference