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Anti-MAGE-1 [6C-1]

Info

Applications WB
Antigen/Gene or Protein Targets MAGE-1
Synonyms MAGE Family Member A1; Melanoma-Associated Antigen MZ2-E; Cancer/Testis Antigen 1.1; Melanoma Antigen MAGE-1; MAGE-1 Antigen; Antigen MZ2-E; CT1.1; Cancer/Testis Antigen Family 1; MAGE1A
Reactivity Human
Relevance Human malignant neoplasms carry rejection antigens that are recognized by the patients autologous, tumor directed and specific, cytolytic, CD8+T lymphocyte clones (CTL). An important group of antigens is coded by the MAGE family of genes. It was identified that melanomas and primary glial brain tumors express common melanoma associated antigens (MAAs). Because MAGE-1 is expressed on a significant proportion of human neoplasms of various histological types (melanoma, brain tumors of glial origin, neuroblastoma, non-small cell lung cancer, breast, gastric, colorectal, ovarian, renal cell carcinomas) and not on normal tissues, the encoded antigen may serve as a marker of early detection and target for cancer immunotherapy.
Host Mouse
Subclass IgG2a
Research Area Cancer, Cell Type or Organelle Marker

References: 1 entry

Rimoldi et al. 2000. Int J Cancer. 86(5):749-51. PMID: 10797302.


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References: 1 entry

Rimoldi et al. 2000. Int J Cancer. 86(5):749-51. PMID: 10797302.


Add a reference

References: 1 entry

Rimoldi et al. 2000. Int J Cancer. 86(5):749-51. PMID: 10797302.


Add a reference


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