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Catalogue Number
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154754 |
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Applications
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FACS
IP
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Antigen/Gene or Protein Targets
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CD3 ε
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Synonyms
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CD3E; T-Cell Surface Glycoprotein CD3 Epsilon Chain
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Reactivity
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Human
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Relevance
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The CD3-epsilon polypeptide together with CD3-gamma, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development. Defects in this gene cause severe immunodeficiency.
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Host
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Mouse
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Immunogen
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Human cytotoxic T-lymphocytes
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Subclass
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IgG2b
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Myeloma Used
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Sp2/0-Ag14
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Recommended Growing Conditions
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IMDM + 4% FBS ultra low IgG, 37 ⁰C 5% CO2
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Strain
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Balb/c
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Notes
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Fusion partners: SP2/0 x spleen cells origin BALB/C.
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Research Area
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Cell Signaling & Signal Transduction, Immunology
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