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Anti-CD3 ε [NKIT3a] monoclonal Antibody
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Info

Catalogue Number 154754
Applications FACS IP
Antigen/Gene or Protein Targets CD3 ε
Synonyms CD3E; T-Cell Surface Glycoprotein CD3 Epsilon Chain
Reactivity Human
Relevance The CD3-epsilon polypeptide together with CD3-gamma, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development. Defects in this gene cause severe immunodeficiency.
Host Mouse
Immunogen Human cytotoxic T-lymphocytes
Subclass IgG2b
Myeloma Used Sp2/0-Ag14
Recommended Growing Conditions IMDM + 4% FBS ultra low IgG, 37 ⁰C 5% CO2
Strain Balb/c
Notes Fusion partners: SP2/0 x spleen cells origin BALB/C.
Research Area Cell Signaling & Signal Transduction, Immunology

References

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References: 1 entry

Spits et al. 1983. Hybridoma. 2(4):423-37. PMID: 6332061.


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References: 1 entry

Spits et al. 1983. Hybridoma. 2(4):423-37. PMID: 6332061.


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