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Anti-IL-27p28 [MM27-7B1]

Info

Applications ELISA FACS
Antigen/Gene or Protein Targets IL-27p28
Synonyms Interleukin 27; IL-27 Subunit Alpha; Interleukin 30; IL27A; IL30; P28; IL-27 P28 Subunit 3
Reactivity Mouse
Relevance IL-27 is a heterodimeric cytokine that consists of EBI3, an IL-12p40-related protein, and p28, an IL-12p35-related polypeptide. IL-27 can be allocated to the IL-6/IL-12 superfamily of cytokines which include also IL-23. This family is defined based on similarities in the structural motifs of the ligands, such as a common four-helix bundle, their receptors, which contain a hematopoietin receptor domain. IL-27 signaling occurs via a receptor complex composed of the signal transducing receptor chains WSX-1 and glycoprotein (gp) 130. Whereas WSX-1 is the IL-27–specific receptor chain, gp130 is the common receptor subunit of IL-6 type cytokines. IL-27 signaling in naïve CD4+ T cells leads to activation and phosphorylation of STAT1 and STAT3.
Host Mouse
Subclass IgG2a
Research Area Cancer, Cell Signaling & Signal Transduction, Immunology

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