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|Applications||ELISA IF WB|
|Antigen/Gene or Protein Targets||SC35 (Splicing factor R/S-rich 2. SRSF2)|
|Reactivity||Human and Mouse|
|Relevance||SC35 is necessary for the splicing of pre-mRNA. It is required for formation of the earliest ATP-dependent splicing complex and interacts with spliceosomal components bound to both the 5'- and 3'-splice sites during spliceosome assembly. It also is required for ATP-dependent interactions of both U1 and U2 snRNPs with pre-mRNA. SC35 interacts with other spliceosomal components, via the RS domains, to form a bridge between the 5'- and 3'-splice site binding components, U1 snRNP and U2AF.|
|Immunogen||Synthetic peptide coupled to Ovalbumin (C)-KSPPKSPEEEGAVSS corresponding to aa 207-221 of human SC35|
Recommend dilutions: 1/500 - 1/5000.
Available in 100ul units.
|Research Area||Epigenetics & Nuclear Signalling|
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