Anti-ABCD2 [1AL-2B4]
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| Applications | IHC IF WB |
| Antigen/Gene or Protein Targets | ALDP (Adenoleucodistrophy protein) |
| Reactivity | Human |
| Relevance | The 2B4 antibody can be used in western blot, immunofluorescence or immunohistochemical studies to analyse the ALDP protein in cells and tissues for normal individuals, or from patients with adrenoleukodystrophy (ALD) or Zellweger syndrome and related peroxisomal diseases, and provides an excellent marker for peroxisomes (Mosser et al. 1994). About 70% of ALD male patients have no detectable ALDP in fibroblasts or leukocytes. A similar proportion of carrier females may show mosaïcism for the presence or absence of ALDP. |
| Host | Mouse |
| Immunogen | Recombinant protein (495-648) |
| Subclass | IgG1 kappa |
| Notes | Available in 100ul unit as ascites. |
| Research Area | Cancer, Cardiovascular, Cell Type or Organelle Marker, Cell Signaling & Signal Transduction, Cellular Transport, Metabolism |
References: 3 entries
Aubourg et al. 1996. Ann N Y Acad Sci. 804:461-76. PMID: 8993565.
Lombard-Platet et al. 1996. Proc Natl Acad Sci U S A. 93(3):1265-9. PMID: 8577752.
Mosser et al. 1994. Hum Mol Genet. 3(2):265-71. PMID: 8004093.
Add a reference
References: 3 entries
Aubourg et al. 1996. Ann N Y Acad Sci. 804:461-76. PMID: 8993565.
Lombard-Platet et al. 1996. Proc Natl Acad Sci U S A. 93(3):1265-9. PMID: 8577752.
Mosser et al. 1994. Hum Mol Genet. 3(2):265-71. PMID: 8004093.
Add a reference
References: 3 entries
Aubourg et al. 1996. Ann N Y Acad Sci. 804:461-76. PMID: 8993565.
Lombard-Platet et al. 1996. Proc Natl Acad Sci U S A. 93(3):1265-9. PMID: 8577752.
Mosser et al. 1994. Hum Mol Genet. 3(2):265-71. PMID: 8004093.
Add a reference
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