Anti-APC [c-APC 28.9]
Invented by Prof Walter Bodmer from University of Oxford
Invented at Cancer Research UK London Research Institute: Lincoln's Inn Fields
- Datasheet
- References (4)
- Inventor Info
Info
| Catalogue Number | 152092 |
| Applications | IHC IF IP WB |
| Antigen/Gene or Protein Targets | APC |
| Reactivity | Human |
| Relevance |
The adenomatous polyposis coli tumor suppressor gene is mutated (often deletion of the C-terminal portion of APC) in the inherited disease, familial adenomatous polyposis (FAP), and over 80% of colorectal cancers. C-APC 28.8 can be used for APC expression and detection of APC mutations. Clone c-APC 28.9 is useful for the detection of APC expression and detection of mutations. This antibody has been used routinely for Western blotting on colon cell line HCT116 extract which expresses full-length APC. |
| Host | Mouse |
| Immunogen | human APC C-terminal fusion with MBP (maltose binding protein) |
| Positive Control | Colon cell line HCT116 |
| Subclass | IgG1 kappa |
| Research Area | Cancer, Cardiovascular, Cell Cycle, Cell Type or Organelle Marker, Cell Signaling & Signal Transduction, Epigenetics & Nuclear Signalling, Neurobiology, Stem Cell Biology |
References: 4 entries
Kariola et al. 2005. Fam Cancer. 4(2):187-90. PMID: 15951972.
APC and beta-catenin protein expression patterns in HNPCC-related endometrial and colorectal cancers.
Europe PMC ID: 15951972
Fodde et al. 2001. Nat Cell Biol. 3(4):433-8. PMID: 11283620.
Mutations in the APC tumour suppressor gene cause chromosomal instability.
Europe PMC ID: 11283620
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References: 4 entries
Kariola et al. 2005. Fam Cancer. 4(2):187-90. PMID: 15951972.
APC and beta-catenin protein expression patterns in HNPCC-related endometrial and colorectal cancers.
Fodde et al. 2001. Nat Cell Biol. 3(4):433-8. PMID: 11283620.
Mutations in the APC tumour suppressor gene cause chromosomal instability.
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