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|Applications||IHC IF IP WB|
|Antigen/Gene or Protein Targets||APC|
The adenomatous polyposis coli tumor suppressor gene is mutated (often deletion of the C-terminal portion of APC) in the inherited disease, familial adenomatous polyposis (FAP), and over 80% of colorectal cancers. C-APC 28.8 can be used for APC expression and detection of APC mutations.
Clone c-APC 28.9 is useful for the detection of APC expression and detection of mutations. This antibody has been used routinely for Western blotting on colon cell line HCT116 extract which expresses full-length APC.
|Immunogen||human APC C-terminal fusion with MBP (maltose binding protein)|
|Positive Control||Colon cell line HCT116|
|Research Area||Cancer, Cardiovascular, Cell Cycle, Cell Type or Organelle Marker, Cell Signaling & Signal Transduction, Epigenetics & Nuclear Signalling, Neurobiology, Stem Cell Biology|
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