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Anti-APC [c-APC 28.9]

Invented by Prof Walter Bodmer at University of Oxford

Info

Catalogue Number 152092
Applications IHC IF IP WB
Antigen/Gene or Protein Targets APC
Reactivity Human
Relevance The adenomatous polyposis coli tumor suppressor gene is mutated (often deletion of the C-terminal portion of APC) in the inherited disease, familial adenomatous polyposis (FAP), and over 80% of colorectal cancers. C-APC 28.8 can be used for APC expression and detection of APC mutations.

Clone c-APC 28.9 is useful for the detection of APC expression and detection of mutations. This antibody has been used routinely for Western blotting on colon cell line HCT116 extract which expresses full-length APC.
Host Mouse
Immunogen human APC C-terminal fusion with MBP (maltose binding protein)
Subclass IgG1 kappa
Positive Control Colon cell line HCT116
Research Area Cancer, Cardiovascular, Cell Cycle, Cell Type or Organelle Marker, Cell Signaling & Signal Transduction, Epigenetics & Nuclear Signalling, Neurobiology, Stem Cell Biology

References: 4 entries

Kariola et al. 2005. Fam Cancer. 4(2):187-90. PMID: 15951972.

APC and beta-catenin protein expression patterns in HNPCC-related endometrial and colorectal cancers.

Europe PMC ID: 15951972

Fodde et al. 2001. Nat Cell Biol. 3(4):433-8. PMID: 11283620.

Mutations in the APC tumour suppressor gene cause chromosomal instability.

Europe PMC ID: 11283620


Add a reference

References: 4 entries

Kariola et al. 2005. Fam Cancer. 4(2):187-90. PMID: 15951972.

APC and beta-catenin protein expression patterns in HNPCC-related endometrial and colorectal cancers.

Europe PMC ID: 15951972

Fodde et al. 2001. Nat Cell Biol. 3(4):433-8. PMID: 11283620.

Mutations in the APC tumour suppressor gene cause chromosomal instability.

Europe PMC ID: 11283620


Add a reference

References: 4 entries

Kariola et al. 2005. Fam Cancer. 4(2):187-90. PMID: 15951972.

APC and beta-catenin protein expression patterns in HNPCC-related endometrial and colorectal cancers.

Fodde et al. 2001. Nat Cell Biol. 3(4):433-8. PMID: 11283620.

Mutations in the APC tumour suppressor gene cause chromosomal instability.


Add a reference


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