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LIMK inhibitor CRT0105446 Small Molecule (Tool Compound)

Invented by Dr Mark Charles at Cancer Research Technology

Info

Catalogue Number 151878
Antigen/Gene or Protein Targets LIMK1 and LIMK2
Type Inhibitor
Relevance CRT0105446 is a novel, selective, potent LIMK inhibitor, which inhibit p-cofilin and inhibit invasion in a Matrigel inverse invasion assay. LIMK1 has been reported to play a key role in tumour cell invasion1, and the level of LIMK1 is increased in breast and prostate cancer cell lines in comparison with less invasive cell lines. The LIM kinases (LIMK1 and LIMK2) phosphorylate and inactivate cofilin which allows them to act as regulators of actin cytoskeletal dynamics and microtubule organisation.
On Target IC50 IC50 LIMK1:0.001uM
IC50 LIMK2:0.001uM
IC50 Cell p-cofilin:0.6uM
Molecular Formula C20H18F3N3O2S
Molecular Weight (g/mol) 421.44
In vitro applications Potent LIMK inhibitor, which inhibit p-cofilin and inhibit invasion in a Matrigel inverse invasion assay
Research Area Cell Signaling & Signal Transduction, Neurobiology
Notes % invasion inhibition at 3uM: 96
% cell viability at 10uM: 70

References: 1 entry

Charles et al. 2015. J Med Chem. :. PMID: 26356364.


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References: 1 entry

Charles et al. 2015. J Med Chem. :. PMID: 26356364.


Add a reference

References: 1 entry

Charles et al. 2015. J Med Chem. :. PMID: 26356364.


Add a reference


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