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Monoclonal Antibodies

Anti-POT1 [M1-P1H5]

Invented by Ayham Alnabulsi from Vertebrate Antibodies Limited
Invented at Vertebrate Antibodies Limited
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Catalogue Number 151875
Applications ELISA IF WB
Antigen/Gene or Protein Targets Protection of telomeres 1 (POT1)
Reactivity Human
Relevance POT1 (protection of telomeres 1) is part of the telomerase ribonucleotide (RNP) complex, which stabilises chromosomes by controlling telomere elongation. POT1 is a component of the double-stranded telomeric DNA-binding TRF1 complex which cis-inhibits telomerase. POT1 localization on telomeres diminishes in the absence of single-stranded DNA.
Host Mouse
Immunogen Peptide sequence - IPASEVLMDD
Positive Control ELISA- Peptide immunogenWestern Blot- Hela cell extract (nuclear fraction)IF- Hela Cells
Subclass IgG1 kappa
Recommended Growing Conditions Dulbecco’s media containing 20% Fetal Bovine serum (DH20) prepared as follows (for final volume of 300ml: 237ml DMEM + 60 ml Fetal Bovine Serum plus 3ml L-Glutamine + 3ml of Penicillin -Streptomycin.
Strain Balb/c
Notes BLAST analysis of immunogen peptide has revealed 100% identity to mouse and rat
Research Area Cancer, Cell Cycle, Epigenetics & Nuclear Signalling

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