Anti-BCL10 [151]
Invented at University College London
- Datasheet
- References (6)
- Inventor Info
Info
| Catalogue Number | 151821 |
| Applications | ELISA IHC WB |
| Antigen/Gene or Protein Targets | Bcl10 |
| Reactivity | Human |
| Relevance | BCL-10 is an apoptotic regulatory molecule, of approximately 31 kDa. It was identified through its direct involvement in t(1:14) (p22;q32) of mucosa-associated lymphoid tissue (MALT) lymphoma. In B-cell follicles, BCL10 has been shown to be expressed abundantly in the germinal center B cells, moderately in the marginal zone, but only weakly in mantle zone B cells. This differential expression is an indicator of its importance in maturation and malignant transformation of human B-cells. BCL-10 contains a caspase recruitment domain (CARD), and has been shown to induce apoptosis and to activate NF-kappaB. |
| Host | Mouse |
| Immunogen | Full-length recombinant BCL-10 protein |
| Subclass | IgG1 kappa |
| Myeloma Used | NS0 |
| Strain | Balb/c |
| Notes | IHC-P: 1/25 - 1/100 in an ABC method. Antibody incubation period of 30 minutes at room temperature is recommended. Perform heat mediated antigen retrieval with 10mM citrate buffer, pH 6.0 before commencing with IHC staining protocol. |
| Research Area | Apoptosis and Programmed Cell Death, Cancer, Cell Signaling & Signal Transduction, Metabolism |
References: 6 entries
Shen et al. 2003. Blood. 102(4):1553-4. PMID: 12900354.
Aberrant BCL10 nuclear expression in nasal NK/T-cell lymphoma.
Europe PMC ID: 12900354
Ye et al. 2000. Am J Pathol. 157(4):1147-54. PMID: 11021819.
BCL10 expression in normal and neoplastic lymphoid tissue. Nuclear localization in MALT lymphoma.
Europe PMC ID: 11021819
Du et al. 2000. Blood. 95(12):3885-90. PMID: 10845924.
BCL10 gene mutation in lymphoma.
Europe PMC ID: 10845924
Add a reference
References: 6 entries
Shen et al. 2003. Blood. 102(4):1553-4. PMID: 12900354.
Aberrant BCL10 nuclear expression in nasal NK/T-cell lymphoma.
Ye et al. 2000. Am J Pathol. 157(4):1147-54. PMID: 11021819.
BCL10 expression in normal and neoplastic lymphoid tissue. Nuclear localization in MALT lymphoma.
Du et al. 2000. Blood. 95(12):3885-90. PMID: 10845924.
BCL10 gene mutation in lymphoma.
Add a reference
