Cat. #151821
Anti-BCL10 [151]
Cat. #: 151821
Sub-type: Primary antibody
Unit size: 100 ug
Availability: 3-4 weeks
Target: Bcl10
Class: Monoclonal
Application: ELISA ; IHC ; WB
Reactivity: Human
Host: Mouse
£300.00
This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.
Contributor
Inventor: Ming-Qing Du
Institute: University College London (UCL)
Tool Details
*FOR RESEARCH USE ONLY
- Name: Anti-BCL10 [151]
- Clone: 151
- Tool sub type: Primary antibody
- Class: Monoclonal
- Conjugation: Unconjugated
- Strain: Balb/c
- Reactivity: Human
- Host: Mouse
- Application: ELISA ; IHC ; WB
- Description: BCL-10 is an apoptotic regulatory molecule, of approximately 31 kDa. It was identified through its direct involvement in t(1:14) (p22;q32) of mucosa-associated lymphoid tissue (MALT) lymphoma. In B-cell follicles, BCL10 has been shown to be expressed abundantly in the germinal center B cells, moderately in the marginal zone, but only weakly in mantle zone B cells. This differential expression is an indicator of its importance in maturation and malignant transformation of human B-cells. BCL-10 contains a caspase recruitment domain (CARD), and has been shown to induce apoptosis and to activate NF-kappaB.
- Immunogen: Full-length recombinant BCL-10 protein
- Isotype: IgG1 kappa
- Myeloma used: NS0
Target Details
- Target: Bcl10
- Target background: BCL-10 is an apoptotic regulatory molecule, of approximately 31 kDa. It was identified through its direct involvement in t(1:14) (p22;q32) of mucosa-associated lymphoid tissue (MALT) lymphoma. In B-cell follicles, BCL10 has been shown to be expressed abundantly in the germinal center B cells, moderately in the marginal zone, but only weakly in mantle zone B cells. This differential expression is an indicator of its importance in maturation and malignant transformation of human B-cells. BCL-10 contains a caspase recruitment domain (CARD), and has been shown to induce apoptosis and to activate NF-kappaB.
Applications
- Application: ELISA ; IHC ; WB
Handling
- Format: Liquid
- Concentration: 0.9-1.1 mg/ml
- Unit size: 100 ug
- Storage buffer: PBS with 0.02% azide
- Storage conditions: -15° C to -25° C
- Shipping conditions: Shipping at 4° C
References
- Shen et al. 2003. Blood. 102(4):1553-4. PMID: 12900354.
- Aberrant BCL10 nuclear expression in nasal NK/T-cell lymphoma.
- Ye et al. 2000. Am J Pathol. 157(4):1147-54. PMID: 11021819.
- BCL10 expression in normal and neoplastic lymphoid tissue. Nuclear localization in MALT lymphoma.
- Du et al. 2000. Blood. 95(12):3885-90. PMID: 10845924.
- BCL10 gene mutation in lymphoma.
