Anti-BLK [BLK154/D4]
Invented by Dr Jacqueline Cordell from University of Oxford
Invented at University of Oxford
- Datasheet
- References (8)
- Inventor Info
Info
| Catalogue Number | 151789 |
| Applications | WB |
| Antigen/Gene or Protein Targets | BLK |
| Reactivity | Human |
| Relevance | B lymphoid tyrosine kinase is a member of the src family of proto-oncogenes that are involved in cell proliferation and differentiation1. It is expressed in B cells during all stages of development and has a role in B-cell receptor signaling and B-cell development2,3. BLK also stimulates insulin synthesis and secretion in response to glucose by up regulating pancreatic beta-cell transcription factors. |
| Host | Mouse |
| Immunogen | Recombinant protein corresponding to amino acids 53- 224 of human BLK |
| Positive Control | Human B cell line |
| Subclass | IgG1 |
| Myeloma Used | NS0 |
| Recommended Growing Conditions | RPMI 1640 + 10% FCS + penicillin (100U/ml) + streptomycin (100mg/l) + glutamine (2mM) + HAT |
| Research Area | Apoptosis and Programmed Cell Death |
References: 8 entries
Borowiec et al. 2009. Proc Natl Acad Sci U S A. 106(34):14460-5. PMID: 19667185.
Mutations at the BLK locus linked to maturity onset diabetes of the young and beta-cell dysfunction.
Europe PMC ID: 19667185
Wasserman et al. 1995. J Immunol. 155(2):644-51. PMID: 7608542.
Differential expression of the blk and ret tyrosine kinases during B lineage development is dependent on Ig rearrangement.
Europe PMC ID: 7608542
Islam et al. 1995. J Immunol. 154(3):1265-72. PMID: 7822795.
Molecular cloning, characterization, and chromosomal localization of a human lymphoid tyrosine kinase related to murine Blk.
Europe PMC ID: 7822795
Yao et al. 1993. Proc Natl Acad Sci U S A. 90(17):7946-50. PMID: 7690139.
Antisense oligodeoxynucleotides to the blk tyrosine kinase prevent anti-mu-chain-mediated growth inhibition and apoptosis in a B-cell lymphoma.
Europe PMC ID: 7690139
Add a reference
References: 8 entries
Borowiec et al. 2009. Proc Natl Acad Sci U S A. 106(34):14460-5. PMID: 19667185.
Mutations at the BLK locus linked to maturity onset diabetes of the young and beta-cell dysfunction.
Wasserman et al. 1995. J Immunol. 155(2):644-51. PMID: 7608542.
Differential expression of the blk and ret tyrosine kinases during B lineage development is dependent on Ig rearrangement.
Islam et al. 1995. J Immunol. 154(3):1265-72. PMID: 7822795.
Molecular cloning, characterization, and chromosomal localization of a human lymphoid tyrosine kinase related to murine Blk.
Yao et al. 1993. Proc Natl Acad Sci U S A. 90(17):7946-50. PMID: 7690139.
Antisense oligodeoxynucleotides to the blk tyrosine kinase prevent anti-mu-chain-mediated growth inhibition and apoptosis in a B-cell lymphoma.
Add a reference
