Cat. #151789
Anti-BLK [BLK154/D4]
Cat. #: 151789
Sub-type: Primary antibody
Unit size: 100 ug
Availability: 10-12 weeks
Target: BLK
Class: Monoclonal
Application: WB
Reactivity: Human
Host: Mouse
£300.00
This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.
Contributor
Inventor: Jacqueline Cordell
Institute: University of Oxford
Tool Details
*FOR RESEARCH USE ONLY
- Name: Anti-BLK [BLK154/D4]
- Clone: BLK154/D4
- Tool sub type: Primary antibody
- Class: Monoclonal
- Conjugation: Unconjugated
- Reactivity: Human
- Host: Mouse
- Application: WB
- Description: B lymphoid tyrosine kinase is a member of the src family of proto-oncogenes that are involved in cell proliferation and differentiation1. It is expressed in B cells during all stages of development and has a role in B-cell receptor signaling and B-cell development2,3. BLK also stimulates insulin synthesis and secretion in response to glucose by up regulating pancreatic beta-cell transcription factors.
- Immunogen: Recombinant protein corresponding to amino acids 53- 224 of human BLK
- Isotype: IgG1
- Myeloma used: NS0
- Recommended controls: Human B cell line
Target Details
- Target: BLK
- Tissue cell line specificity: Human B cell line
- Target background: B lymphoid tyrosine kinase is a member of the src family of proto-oncogenes that are involved in cell proliferation and differentiation1. It is expressed in B cells during all stages of development and has a role in B-cell receptor signaling and B-cell development2,3. BLK also stimulates insulin synthesis and secretion in response to glucose by up regulating pancreatic beta-cell transcription factors.
Applications
- Application: WB
Handling
- Format: Liquid
- Concentration: 0.9-1.1 mg/ml
- Unit size: 100 ug
- Storage buffer: PBS with 0.02% azide
- Storage conditions: -15° C to -25° C
- Shipping conditions: Shipping at 4° C
References
- Borowiec et al. 2009. Proc Natl Acad Sci U S A. 106(34):14460-5. PMID: 19667185.
- Mutations at the BLK locus linked to maturity onset diabetes of the young and beta-cell dysfunction.
- Wasserman et al. 1995. J Immunol. 155(2):644-51. PMID: 7608542.
- Differential expression of the blk and ret tyrosine kinases during B lineage development is dependent on Ig rearrangement.
- Islam et al. 1995. J Immunol. 154(3):1265-72. PMID: 7822795.
- Molecular cloning, characterization, and chromosomal localization of a human lymphoid tyrosine kinase related to murine Blk.
- Yao et al. 1993. Proc Natl Acad Sci U S A. 90(17):7946-50. PMID: 7690139.
- Antisense oligodeoxynucleotides to the blk tyrosine kinase prevent anti-mu-chain-mediated growth inhibition and apoptosis in a B-cell lymphoma.
