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Anti-Tdp2, Polyclonal [Tdp2]

Info

Catalogue Number 151785
Applications WB
Antigen/Gene or Protein Targets Tdp2
Reactivity Human
Relevance DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 5'-phosphodiester bond, giving rise to DNA with a free 5' phosphate. Catalyzes the hydrolysis of dead-end complexes between DNA and the topoisomerase 2 (TOP2) active site tyrosine residue. Hydrolyzes 5'- phosphoglycolates on protruding 5' ends on DNA double-strand breaks (DSBs) due to DNA damage by radiation and free radicals. The 5'-tyrosyl DNA phosphodiesterase activity can enable the repair of TOP2-induced DSBs without the need for nuclease activity, creating a 'clean' DSB with 5'-phosphate termini that are ready for ligation. Has also 3'-tyrosyl DNA phosphodiesterase activity, but less efficiently and much slower than TDP1. May also act as a negative regulator of ETS1 and may inhibit nuclear factor-kappa-B activation.
Host Rabbit
Immunogen Recombinant human protein with his tag
Molecular Weight (kDa) 49
Notes Suggested Dilutions: 1:1000 - 1:10000
Positive Control A549
Research Area Cancer, Epigenetics & Nuclear Signalling

References: 1 entry

Thomson et al. 2013. Anal Biochem. 436(2):145-50. PMID: 23416181.


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References: 1 entry

Thomson et al. 2013. Anal Biochem. 436(2):145-50. PMID: 23416181.


Add a reference

References: 1 entry

Thomson et al. 2013. Anal Biochem. 436(2):145-50. PMID: 23416181.


Add a reference


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