Anti-ASPP1, Polyclonal [ASPP1]
Invented at University of Newcastle upon Tyne
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- References (2)
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Info
| Catalogue Number | 151751 |
| Applications | IF IP WB |
| Antigen/Gene or Protein Targets | ASPP1 |
| Reactivity | Human |
| Relevance | Stimulating protein of p53 (ASPP) contains four ankyrin repeats and an SH3 domain involved in protein-protein interactions. ASPP proteins are required for the induction of apoptosis by p53-family proteins. They promote DNA binding and transactivation of p53-family proteins on the promoters of proapoptotic genes. Expression of this gene is regulated by the E2F transcription factor. There are three known types of ASPP: ASPP1, ASPP2 and iASPP1. iASPP1 inhibits the proaptotic functions of ASPP1 and p53. |
| Host | Sheep |
| Immunogen | Amino acids from human ASPP1 357-532 |
| Research Area | Cancer, Stem Cell Biology |
References: 2 entries
Thornton et al. 2006. Oncogene. 25(22):3104-12. PMID: 16474851.
The tumour-suppressor protein ASPP1 is nuclear in human germ cells and can modulate ratios of CD44 exon V5 spliced isoforms in vivo.
Europe PMC ID: 16474851
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References: 2 entries
Thornton et al. 2006. Oncogene. 25(22):3104-12. PMID: 16474851.
The tumour-suppressor protein ASPP1 is nuclear in human germ cells and can modulate ratios of CD44 exon V5 spliced isoforms in vivo.
Add a reference
