#151751

Anti-ASPP1 [ASPP1]

Cat. #151751

Anti-ASPP1 [ASPP1]

Cat. #: 151751

Sub-type: Primary antibody

Unit size: 100 ug

Availability: 10-12 weeks

Target: ASPP1

Class: Polyclonal

Application: IF ; IP ; WB

Reactivity: Human

Host: Sheep

£300.00

This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.

Contributor

Inventor: David Elliott

Institute: Newcastle University

Tool Details
Target Details
Applications
Handling
References

Tool Details

*FOR RESEARCH USE ONLY

  • Name: Anti-ASPP1 [ASPP1]
  • Clone: ASPP1
  • Tool sub type: Primary antibody
  • Class: Polyclonal
  • Conjugation: Unconjugated
  • Reactivity: Human
  • Host: Sheep
  • Application: IF ; IP ; WB
  • Description: iASPP1 inhibits the proaptotic functions of ASPP1 and p53.
  • Immunogen: Amino acids from human ASPP1 357-532

Target Details

  • Target: ASPP1
  • Target background: Stimulating protein of p53 (ASPP) contains four ankyrin repeats and an SH3 domain involved in protein-protein interactions. ASPP proteins are required for the induction of apoptosis by p53-family proteins. They promote DNA binding and transactivation of p53-family proteins on the promoters of proapoptotic genes. Expression of this gene is regulated by the E2F transcription factor. There are three known types of ASPP: ASPP1, ASPP2 and iASPP1.

Applications

  • Application: IF ; IP ; WB

Handling

  • Format: Liquid
  • Concentration: 0.9-1.1 mg/ml
  • Unit size: 100 ug
  • Storage conditions: -15° C to -25° C
  • Shipping conditions: Shipping at 4° C

References

  • Thornton et al. 2006. Oncogene. 25(22):3104-12. PMID: 16474851.
  • The tumour-suppressor protein ASPP1 is nuclear in human germ cells and can modulate ratios of CD44 exon V5 spliced isoforms in vivo.