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Anti-Cytochrome P450 2A6, Polyclonal [CYP2A6]

Invented by Prof Roland Wolf at University of Dundee

Info

Catalogue Number 151723
Applications WB
Antigen/Gene or Protein Targets Cytochrome P450 2A6, CYP2A6
Reactivity Human
Relevance CYP2A6, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to hydroxylate coumarin, and also metabolizes nicotine, aflatoxin B1, nitrosamines, and some pharmaceuticals. This gene is part of a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q. CYP 2A6 exhibits high coumarin 7-hydroxylase activity and can act in the hydroxylation of the anti-cancer drugs cyclophosphamide and ifosphamide.
Host Sheep
Immunogen Purified recombinant human P450s
Positive Control Human Liver Microsomes
Research Area Cancer, Cardiovascular, Cell Signaling & Signal Transduction, Epigenetics & Nuclear Signalling, Metabolism

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