Cat. #151723
Anti-Cytochrome P450 2A6 [CYP2A6]
Cat. #: 151723
Sub-type: Primary antibody
Unit size: 100 ug
Availability: 10-12 weeks
Target: Cytochrome P450 2A6, CYP2A6
Class: Polyclonal
Application: WB
Reactivity: Human
Host: Sheep
£300.00
This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.
Contributor
Inventor: Roland Wolf
Institute: University of Dundee
Tool Details
*FOR RESEARCH USE ONLY
- Name: Anti-Cytochrome P450 2A6 [CYP2A6]
- Clone: CYP2A6
- Tool sub type: Primary antibody
- Class: Polyclonal
- Conjugation: Unconjugated
- Reactivity: Human
- Host: Sheep
- Application: WB
- Description: CYP2A6, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to hydroxylate coumarin, and also metabolizes nicotine, aflatoxin B1, nitrosamines, and some pharmaceuticals. This gene is part of a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q. CYP 2A6 exhibits high coumarin 7-hydroxylase activity and can act in the hydroxylation of the anti-cancer drugs cyclophosphamide and ifosphamide.
- Immunogen: Purified recombinant human P450s
- Recommended controls: Human Liver Microsomes
Target Details
- Target: Cytochrome P450 2A6, CYP2A6
- Tissue cell line specificity: Human Liver Microsomes
- Target background: CYP2A6, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to hydroxylate coumarin, and also metabolizes nicotine, aflatoxin B1, nitrosamines, and some pharmaceuticals. This gene is part of a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q. CYP 2A6 exhibits high coumarin 7-hydroxylase activity and can act in the hydroxylation of the anti-cancer drugs cyclophosphamide and ifosphamide.
Applications
- Application: WB
Handling
- Format: Liquid
- Unit size: 100 ug
- Storage conditions: -80° C
- Shipping conditions: Shipping at 4° C
