| Catalogue Number | 151695 |
| Antigen/Gene or Protein Targets | Fibroblast growth factor receptor 2 isoform IIIb (FGFR2IIIb) |
| Disease Keywords | Gastric |
| Relevance | Knockout of FGFR2 IIIb isoform; in vivo study of FGFR2 IIIb isoform knockout. |
| Production Details | An Fgfr2 targeting vector, containing a loxP-flanked IIIb exon and a loxP-flanked resistance cassette, was transfected into 129 ES cells. Properly targeted ES cells containing a homologous recombination event were selected, and transfected with a Cre expression vector to excise the resistance cassette. Targeted ES cells were injected into C57BL/6 blastocysts. Chimeric offspring were mated to C57BL/6 mice to generate mice heterozygous for the floxed Fgfr2 allele. Heterozygous mice were interbred to generate mice homozygous for the floxed Fgfr2 allele. |
| Conditional | No |
| Mouse Genetic Background/Cross History | 129/C57BL/6 |
| Zygosity | Homozygous |
| Research Area | Cancer, Cell Signaling & Signal Transduction, Genetic Studies Tools, Immunology |
Grose et al. 2007. EMBO J. 26(5):1268-78. PMID: 17304214.
The role of fibroblast growth factor receptor 2b in skin homeostasis and cancer development.
Europe PMC ID: 17304214
De Moerlooze et al. 2000. Development. 127(3):483-92. PMID: 10631169.
An important role for the IIIb isoform of fibroblast growth factor receptor 2 (FGFR2) in mesenchymal-epithelial signalling during mouse organogenesis.
Europe PMC ID: 10631169
Grose et al. 2007. EMBO J. 26(5):1268-78. PMID: 17304214.
The role of fibroblast growth factor receptor 2b in skin homeostasis and cancer development.
De Moerlooze et al. 2000. Development. 127(3):483-92. PMID: 10631169.
An important role for the IIIb isoform of fibroblast growth factor receptor 2 (FGFR2) in mesenchymal-epithelial signalling during mouse organogenesis.
