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FGFR2b Mouse

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Catalogue Number 151695
Antigen/Gene or Protein Targets Fibroblast growth factor receptor 2 isoform IIIb (FGFR2IIIb)
Disease Keywords Gastric
Relevance Knockout of FGFR2 IIIb isoform; in vivo study of FGFR2 IIIb isoform knockout.
Production Details An Fgfr2 targeting vector, containing a loxP-flanked IIIb exon and a loxP-flanked resistance cassette, was transfected into 129 ES cells. Properly targeted ES cells containing a homologous recombination event were selected, and transfected with a Cre expression vector to excise the resistance cassette. Targeted ES cells were injected into C57BL/6 blastocysts. Chimeric offspring were mated to C57BL/6 mice to generate mice heterozygous for the floxed Fgfr2 allele. Heterozygous mice were interbred to generate mice homozygous for the floxed Fgfr2 allele.
Conditional No
Mouse Genetic Background/Cross History 129/C57BL/6
Zygosity Homozygous
Research Area Cancer, Cell Signaling & Signal Transduction, Genetic Studies Tools, Immunology

References: 4 entries

Grose et al. 2007. EMBO J. 26(5):1268-78. PMID: 17304214.

The role of fibroblast growth factor receptor 2b in skin homeostasis and cancer development.

Europe PMC ID: 17304214

De Moerlooze et al. 2000. Development. 127(3):483-92. PMID: 10631169.

An important role for the IIIb isoform of fibroblast growth factor receptor 2 (FGFR2) in mesenchymal-epithelial signalling during mouse organogenesis.

Europe PMC ID: 10631169


Add a reference

References: 4 entries

Grose et al. 2007. EMBO J. 26(5):1268-78. PMID: 17304214.

The role of fibroblast growth factor receptor 2b in skin homeostasis and cancer development.

Europe PMC ID: 17304214

De Moerlooze et al. 2000. Development. 127(3):483-92. PMID: 10631169.

An important role for the IIIb isoform of fibroblast growth factor receptor 2 (FGFR2) in mesenchymal-epithelial signalling during mouse organogenesis.

Europe PMC ID: 10631169


Add a reference

References: 4 entries

Grose et al. 2007. EMBO J. 26(5):1268-78. PMID: 17304214.

The role of fibroblast growth factor receptor 2b in skin homeostasis and cancer development.

De Moerlooze et al. 2000. Development. 127(3):483-92. PMID: 10631169.

An important role for the IIIb isoform of fibroblast growth factor receptor 2 (FGFR2) in mesenchymal-epithelial signalling during mouse organogenesis.


Add a reference


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