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FGFR2III Floxed Mouse

Info

Catalogue Number 151654
Antigen/Gene or Protein Targets Fibroblast growth factor receptor 2 isoform IIIb (FGFR2IIIb)
Disease Keywords Cancer; gastric cancer;
Relevance Conditional knockout of FGFR2 IIIb isoform; in vivo study of FGFR2 IIIb isoform knockout
Production Details An Fgfr2 targeting vector, containing a loxP flanked IIIb exon and a loxP flanked resistance cassette, was transfected into 129Ola ES cells.Properly targeted ES cells containing a homologous recombination event were selected, and transfected with a cre expression vector to excise the resistance cassette. Targeted ES cells were injected into C57BL6 blastocysts. Chimeric offspring were mated to C57BL6 mice to generate heterozygotes. Heterozygotes were bred to homozygosity to generate Fgfr2bflox/flox mice.
Conditional Yes
Conditional Description LoxP flanked IIIb exon of FGFR2 gene enabling tissue-specific cre-mediated knockout of IIIb isoform.
Strain C57BL/6
Mouse Genetic Background/Cross History 129/C57BL6
Zygosity Homozygous
Research Area Cancer, Cell Signaling & Signal Transduction, Genetic Studies Tools, Immunology

References: 2 entries

Grose et al. 2007. EMBO J. 26(5):1268-78. PMID: 17304214.

De Moerlooze et al. 2000. Development. 127(3):483-92. PMID: 10631169.


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References: 2 entries

Grose et al. 2007. EMBO J. 26(5):1268-78. PMID: 17304214.

De Moerlooze et al. 2000. Development. 127(3):483-92. PMID: 10631169.


Add a reference

References: 2 entries

Grose et al. 2007. EMBO J. 26(5):1268-78. PMID: 17304214.

De Moerlooze et al. 2000. Development. 127(3):483-92. PMID: 10631169.


Add a reference


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