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Anti-WIPI2 [2A2]

Invented by Dr Sharon Tooze at The Francis Crick Institute

Info

Catalogue Number 151651
Applications FACS IF IP WB
Antigen/Gene or Protein Targets WIPI2
Reactivity Human and Mouse
Relevance This antibody is useful for the detection of WIPI-2, an essential protein for autophagy. WIPI2 is a mammalian effector of PtdIns3P and is ubiquitously expressed in a variety of cell lines. WIPI2 is recruited to early autophagosomal structures along with Atg16L and ULK1 and is required for the formation of LC3-positive autophagosomes. WIPI-2 is the mammalian homologue of Atg18.
Host Mouse
Immunogen Synthetic peptide corresponding to C-terminus of WIPI2b CSALRLDEDSEHPPMILRTD
Subclass IgG1 kappa
Positive Control HEK293 cells
Molecular Weight (kDa) 49
Recommended Growing Conditions DMEM + 15% FCS
Notes Autophagosomes only detectable after induction of autophagy.
Research Area Cancer, Cardiovascular, Protein Degradation

References: 5 entries

Nishimura et al. 2017. EMBO J. 36(12):1719-1735. PMID: 28495679.

IF

Martinez-Martin et al. 2017. Science. 355(6325):641-647. PMID: 28183981.

FACS

Polson et al. 2010. Autophagy. 6(4):506-22. PMID: 20505359.

Li et al. 2005. J Biol Chem. 280(29):26941-52. PMID: 15917248.

Benzeno et al. 2004. Cancer Res. 64(11):3885-91. PMID: 15172998.


Add a reference

References: 5 entries

Nishimura et al. 2017. EMBO J. 36(12):1719-1735. PMID: 28495679.

IF

Martinez-Martin et al. 2017. Science. 355(6325):641-647. PMID: 28183981.

FACS

Polson et al. 2010. Autophagy. 6(4):506-22. PMID: 20505359.

Li et al. 2005. J Biol Chem. 280(29):26941-52. PMID: 15917248.

Benzeno et al. 2004. Cancer Res. 64(11):3885-91. PMID: 15172998.


Add a reference

References: 5 entries

Nishimura et al. 2017. EMBO J. 36(12):1719-1735. PMID: 28495679.

IF

Martinez-Martin et al. 2017. Science. 355(6325):641-647. PMID: 28183981.

FACS

Polson et al. 2010. Autophagy. 6(4):506-22. PMID: 20505359.

Li et al. 2005. J Biol Chem. 280(29):26941-52. PMID: 15917248.

Benzeno et al. 2004. Cancer Res. 64(11):3885-91. PMID: 15172998.


Add a reference


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