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Inva3b1 Mouse


Catalogue Number 151549
Antigen/Gene or Protein Targets Alpha3 intergrin, beta1 integrin
Disease Keywords Psoriasis
Relevance Disease model for psoriasis; in vivo study of human alpha3 and beta1 integrin transgene expression in skin.
Production Details Involucrin - integrin transgene expression constructs were injected into fertilized oocytes from F1 hybrid CBAxC57Bl/6 mice. Transgene-positive mice were back-crossed to generate individual founder lines. alpha3 founder line was crossed with beta1 founder line to generate alpha3beta1 line.
Conditional Yes
Conditional Description Conditional expression of integrins under involucrin promoter giving tissue-specific suprabasal epidermal expression.
Growth/Phenotype Keywords Skin abnormalities (abnormal keratinocyte differentiation, hyperproliferation, inflammatory lesions)
Mouse Genetic Background/Cross History CBA/C57BL/6
Zygosity Heterozygous
Research Area Cell Type or Organelle Marker, Genetic Studies Tools
Notes Mice present phenotype very similar to human psoriasis disease.

References: 1 entry

Carroll et al. 1995. Cell. 83(6):957-68. PMID: 8521519.

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