Cat. #151549
Inva3b1 Mouse
Cat. #: 151549
Sub-type: Mouse
Availability: 6-8 weeks
Disease: Psoriasis
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Contributor
Inventor: Fiona Watt
Institute: Cancer Research UK, London Research Institute: Lincoln's Inn Fields
Tool Details
*FOR RESEARCH USE ONLY
- Tool name: Inva3b1 Mouse
- Tool sub type: Mouse
- Disease: Psoriasis
- Conditional: Yes
- Conditional description: Conditional expression of integrins under involucrin promoter giving tissue-specific suprabasal epidermal expression.
- Description: Disease model for psoriasis; in vivo study of human alpha3 and beta1 integrin transgene expression in skin.
- Genetic background: Involucrin - integrin transgene expression constructs were injected into fertilized oocytes from F1 hybrid CBAxC57Bl/6 mice. Transgene-positive mice were back-crossed to generate individual founder lines. alpha3 founder line was crossed with beta1 founder line to generate alpha3beta1 line.
- Phenotype: Mice present phenotype very similar to human psoriasis disease.
- Zygosity: Heterozygous
- Production details: Involucrin - integrin transgene expression constructs were injected into fertilized oocytes from F1 hybrid CBAxC57Bl/6 mice. Transgene-positive mice were back-crossed to generate individual founder lines. alpha3 founder line was crossed with beta1 founder line to generate alpha3beta1 line.
- Additional notes: Mice present phenotype very similar to human psoriasis disease.
Handling
- Shipping conditions: Embryo/Spermatoza- Dry Ice
Target Details
- Target: Alpha3 intergrin, beta1 integrin
References
- Carroll et al. 1995. Cell. 83(6):957-68. PMID: 8521519.
- Suprabasal integrin expression in the epidermis of transgenic mice results in developmental defects and a phenotype resembling psoriasis.
