- References (3)
- Inventor Info
|Applications||FACS IF IP Fn|
|Antigen/Gene or Protein Targets||Integrin alpha v/beta 6|
Monoclonal antibody involved in carcinoma invasion, with high potential as a therapeutic target.
Background and Research Application
Integrins are heterodimeric cell surface receptors composed of alpha and beta subunits, which mediate cell-cell and cell-extracellular matrix attachments. Changes in integrin expression have been shown to be important for the growth and early metastatic capacity of melanoma cells and aberrant integrin expression has been found in many epithelial tumours.
The alpha-V integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin and vWF. Integrin alpha-v beta-6 is upregulated in cancers and during tissue remodelling but is absent from resting adult tissues. Integrin alpha-v beta-6 promotes carcinoma invasion, fibrosis and correlates with poor survival and therefore makes a promising therapeutic target.
This antibody does not recognize alpha V or other alpha V integrins.
|Immunogen||Mouse fibroblasts retrovirally infected with cDNA to human beta6 (3T3b6.19). Cells expressed a mouse/human avb6 chimera.|
|Immunogen UniProt ID||P06756|
|Positive Control||BT20 breast carcinoma, original immunogen.|
|Recommended Growing Conditions||RPMI 1640 + 3% FCS|
Purified using multi-step affinity chromatography with protein A.
Store at -20 degrees frozen. Avoid repeated freeze/thaw cycles.
Points of Interest
Integrin alpha-V beta-6 is shown to mediate RGD-dependent release of TGF-beta-1 from regulatory latency-associated peptide (LAP) and plays a role in the activation of TGF-beta-1.
Recommended Concentration: 10ug/ml
1mg/ml as standard
|Research Area||Adhesion, Cancer, Cardiovascular, Cell Signaling & Signal Transduction, Stem Cell Biology|
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References: 3 entries
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