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Anti-Integrin aVb6 [AvB6 53a.2]

Info

Catalogue Number 151543
Applications FACS IF IP Fn
Antigen/Gene or Protein Targets Integrin alpha v/beta 6
Reactivity Human
Relevance Monoclonal antibody involved in carcinoma invasion, with high potential as a therapeutic target.

Background and Research Application
Integrins are heterodimeric cell surface receptors composed of alpha and beta subunits, which mediate cell-cell and cell-extracellular matrix attachments. Changes in integrin expression have been shown to be important for the growth and early metastatic capacity of melanoma cells and aberrant integrin expression has been found in many epithelial tumours.
The alpha-V integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin and vWF. Integrin alpha-v beta-6 is upregulated in cancers and during tissue remodelling but is absent from resting adult tissues. Integrin alpha-v beta-6 promotes carcinoma invasion, fibrosis and correlates with poor survival and therefore makes a promising therapeutic target.

This antibody does not recognize alpha V or other alpha V integrins.
Host Rat
Immunogen Mouse fibroblasts retrovirally infected with cDNA to human beta6 (3T3b6.19). Cells expressed a mouse/human avb6 chimera.
Immunogen UniProt ID P06756
Positive Control BT20 breast carcinoma, original immunogen.
Subclass IgG2a
Recommended Growing Conditions RPMI 1640 + 3% FCS
Notes Production Details
Purified using multi-step affinity chromatography with protein A.

Storage Conditions
Store at -20 degrees frozen. Avoid repeated freeze/thaw cycles.

Points of Interest
Integrin alpha-V beta-6 is shown to mediate RGD-dependent release of TGF-beta-1 from regulatory latency-associated peptide (LAP) and plays a role in the activation of TGF-beta-1.

Recommended Concentration: 10ug/ml

Concentration
1mg/ml as standard
Research Area Adhesion, Cancer, Cardiovascular, Cell Signaling & Signal Transduction, Stem Cell Biology

References

There are 3 reference entries for this reagent.

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References: 3 entries

Liu et al. 2017. Exp Ther Med. 14(4):3880-3886. PMID: 29042996.

Marsh et al. 2008. Cancer Res. 68(9):3295-303. PMID: 18451156.

alpha vbeta 6 Integrin promotes the invasion of morphoeic basal cell carcinoma through stromal modulation.

Europe PMC ID: 18451156


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References: 3 entries

Liu et al. 2017. Exp Ther Med. 14(4):3880-3886. PMID: 29042996.

Marsh et al. 2008. Cancer Res. 68(9):3295-303. PMID: 18451156.

alpha vbeta 6 Integrin promotes the invasion of morphoeic basal cell carcinoma through stromal modulation.


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Inventor Information

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