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Anti-Integrin aVb6 [AvB6 53a.2]

Info

Catalogue Number 151543
Applications FACS IF IP Fn
Antigen/Gene or Protein Targets Integrin alpha v/beta 6
Reactivity Human
Relevance Integrins are heterodimeric cell surface receptors composed of alpha and beta subunits, which mediate cell-cell and cell-extracellular matrix attachments. Aberrant integrin expression has been found in many epithelial tumours. Changes in integrin expression have been shown to be important for the growth and early metastatic capacity of melanoma cells. Integrin alpha-v beta-6 is upregulated in cancers and during tissue remodelling but is absent from resting adult tissues. Integrin alpha-v beta-6 promotes invasion and correlates with poor survival and therefore makes a promising therapeutic target.
Host Rat
Immunogen Mouse fibroblasts retrovirally infected with cDNA to human beta6 (3T3b6.19). Cells expressed a mouse/human avb6 chimera.
Subclass IgG2a
Positive Control BT20 breast carcinoma, original immunogen.
Recommended Growing Conditions RPMI 1640 + 3% FCS
Notes Recommended Concentration: 10ug/ml
Research Area Adhesion, Cancer, Cardiovascular, Cell Signaling & Signal Transduction, Stem Cell Biology

References: 1 entry

Marsh et al. 2008. Cancer Res. 68(9):3295-303. PMID: 18451156.


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References: 1 entry

Marsh et al. 2008. Cancer Res. 68(9):3295-303. PMID: 18451156.


Add a reference

References: 1 entry

Marsh et al. 2008. Cancer Res. 68(9):3295-303. PMID: 18451156.


Add a reference


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