#151543

Anti-Integrin aVb6 [AvB6 53a.2]

Cat. #151543

Anti-Integrin aVb6 [AvB6 53a.2]

Cat. #: 151543

Sub-type: Primary antibody

Unit size: 100 ug

Availability: 1-2 weeks

Target: Integrin alpha v/beta 6

Class: Monoclonal

Application: FACS ; IF ; IP ; Fn

Reactivity: Human

Host: Rat

£300.00

This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.

Contributor

Inventor: John Marshall

Institute: Queen Mary University of London

Tool Details
Target Details
Applications
Handling
References

Tool Details

*FOR RESEARCH USE ONLY

  • Name: Anti-Integrin aVb6 [AvB6 53a.2]
  • Clone: AvB6 53a.2
  • Tool sub type: Primary antibody
  • Class: Monoclonal
  • Conjugation: Unconjugated
  • Reactivity: Human
  • Host: Rat
  • Application: FACS ; IF ; IP ; Fn
  • Description: Monoclonal antibody involved in carcinoma invasion, with high potential as a therapeutic target.
  • Immunogen: Mouse fibroblasts retrovirally infected with cDNA to human beta6 (3T3b6.19). Cells expressed a mouse/human avb6 chimera.
  • Immunogen uniprot id: P06756
  • Isotype: IgG2a
  • Recommended controls: BT20 breast carcinoma, original immunogen.

Target Details

  • Target: Integrin alpha v/beta 6
  • Tissue cell line specificity: BT20 breast carcinoma, original immunogen.
  • Target background: Integrins are heterodimeric cell surface receptors composed of alpha and beta subunits, which mediate cell-cell and cell-extracellular matrix attachments. Changes in integrin expression have been shown to be important for the growth and early metastatic capacity of melanoma cells and aberrant integrin expression has been found in many epithelial tumours. The alpha-V integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin and vWF. Integrin alpha-v beta-6 is upregulated in cancers and during tissue remodelling but is absent from resting adult tissues. Integrin alpha-v beta-6 promotes carcinoma invasion, fibrosis and correlates with poor survival and therefore makes a promising therapeutic target. This antibody does not recognize alpha V or other alpha V integrins.

Applications

  • Application: FACS ; IF ; IP ; Fn

Handling

  • Format: Liquid
  • Concentration: 1 mg/ml
  • Unit size: 100 ug
  • Storage buffer: PBS with 0.02% azide
  • Storage conditions: Store at -20° C frozen. Avoid repeated freeze / thaw cycles
  • Shipping conditions: Shipping at 4° C

References

  • Liu et al. 2017. Exp Ther Med. 14(4):3880-3886. PMID: 29042996.
  • Marsh et al. 2008. Cancer Res. 68(9):3295-303. PMID: 18451156.
  • alpha vbeta 6 Integrin promotes the invasion of morphoeic basal cell carcinoma through stromal modulation.