Anti-APC11 [AX2.1]
Invented by Julian Gannon from The Francis Crick Institute
Invented at Cancer Research UK London Research Institute: Clare Hall Laboratories
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Info
| Catalogue Number | 151535 |
| Applications | ELISA WB |
| Antigen/Gene or Protein Targets | Anaphase Promoting Complex (APC) 11 |
| Reactivity | Human and Xenopus laevis |
| Relevance | APC11 is the catalytic subunit of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. Specifically, Apc11 acts as an E3 enzyme and is responsible for recruiting E2s to the APC and for mediating the subsequent transfer of ubiquitin to APC substrates in vivo. |
| Host | Mouse |
| Immunogen | Peptide spanning carboxy region of APC11. |
| Positive Control | APC11 immunoprecipitated from Xenopus egg extract |
| Subclass | IgG1 |
| Subclass Notes | Inconclusive |
| Myeloma Used | Sp2/0-Ag14 |
| Recommended Growing Conditions | E4 medium + 10% FCS |
| Strain | Balb/c |
| Research Area | Cell Cycle, Protein Degradation |
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