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Jagged1 Floxed Mouse


Catalogue Number 151482
Antigen/Gene or Protein Targets Jagged1 (Jag1)
Disease Keywords Cancer; autoimmune disease
Relevance Conditional knockout of Jag1; in vivo studies of tissue-specific Jag1 knockout and Notch signalling
Production Details A Jag1 targeting vector, containing a loxP flanked resistance cassette before exon 4 and a loxP site inserted after exon 5, was transfected into 129 ES cells. Properly targeted ES cells containing a homologous recombination event were transfected with a Cre expression vector to excise the resistance cassette, and injected into a C57BL6 blastocyst. Chimeric offspring were mated on a C57BL6 background.
Conditional Yes
Conditional Description Jag1 gene with loxP sites flanking exons 4 & 5 enabling conditional Cre-mediate knockout.
Mouse Genetic Background/Cross History 129/C57BL/6
Zygosity Heterozygous
Research Area Cardiovascular, Cell Signaling & Signal Transduction, Genetic Studies Tools, Neurobiology

References: 1 entry

Brooker et al. 2006. Development. 133(7):1277-86. PMID: 16495313.

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