Anti-CHD4 [CHD4 3F2/4]
Invented at Cancer Research UK London Research Institute: Lincoln's Inn Fields
- Datasheet
- References (6)
- Inventor Info
Info
| Catalogue Number | 151462 |
| Applications | ChIP ELISA FACS IHC IF IP WB |
| Antigen/Gene or Protein Targets | Chromodomain-helicase-DNA-binding protein 4 (CHD4/Mi2b) |
| Reactivity | Mouse and Human |
| Relevance | CHD4/Mi-2b is a component of the nucleosome remodeling and deacetylase (NuRD) complex which is a multi-subunit protein complex containing both histone deacetylase and nucleosome-dependent ATPase subunits. Current models predict that this complex functions primarily in transcriptional repression. Accumulating evidence indicates that NuRD may regulate the transcription of specific genes by interacting with specific transcriptional factors. In addition, the NuRD complex may also participate in genome-wide transcriptional regulation through an association with histone tails. |
| Host | Mouse |
| Immunogen | Synthetic peptide (N- and C- terminal peptides were used for immunisation. 1. ASGLGSPSPCSAGSEEEDM & 2. CSRLANRAPEPPPQQVAQQQ. Which peptide the antibody recognises has not been tested) |
| Subclass | IgG2a |
| Myeloma Used | Sp2/0-Ag14 |
| Recommended Growing Conditions | RPMI + 5% FCS |
| Strain | CD1 |
| Research Area | Epigenetics & Nuclear Signalling, Immunology |
References: 6 entries
Sparmann et al. 2013. EMBO J. 32(11):1598-612. PMID: 23624931.
The chromodomain helicase Chd4 is required for Polycomb-mediated inhibition of astroglial differentiation.
Europe PMC ID: 23624931
Curtis et al. 2012. Mol Cell Biol. 32(7):1312-20. PMID: 22290435.
The chromatin-remodeling enzymes BRG1 and CHD4 antagonistically regulate vascular Wnt signaling.
Europe PMC ID: 22290435
Ramírez et al. 2009. Epigenetics. 4(8):532-6. PMID: 19923891.
The Mi-2/NuRD complex: a critical epigenetic regulator of hematopoietic development, differentiation and cancer.
Europe PMC ID: 19923891
Add a reference
References: 6 entries
Sparmann et al. 2013. EMBO J. 32(11):1598-612. PMID: 23624931.
The chromodomain helicase Chd4 is required for Polycomb-mediated inhibition of astroglial differentiation.
Curtis et al. 2012. Mol Cell Biol. 32(7):1312-20. PMID: 22290435.
The chromatin-remodeling enzymes BRG1 and CHD4 antagonistically regulate vascular Wnt signaling.
Ramírez et al. 2009. Epigenetics. 4(8):532-6. PMID: 19923891.
The Mi-2/NuRD complex: a critical epigenetic regulator of hematopoietic development, differentiation and cancer.
Add a reference
