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Anti-CHD4 [CHD4 3F2/4]

Info

Catalogue Number 151462
Applications ChIP ELISA FACS IHC IF IP WB
Antigen/Gene or Protein Targets Chromodomain-helicase-DNA-binding protein 4 (CHD4/Mi2b)
Reactivity Mouse and Human
Relevance CHD4/Mi-2b is a component of the nucleosome remodeling and deacetylase (NuRD) complex which is a multi-subunit protein complex containing both histone deacetylase and nucleosome-dependent ATPase subunits. Current models predict that this complex functions primarily in transcriptional repression. Accumulating evidence indicates that NuRD may regulate the transcription of specific genes by interacting with specific transcriptional factors. In addition, the NuRD complex may also participate in genome-wide transcriptional regulation through an association with histone tails.
Host Mouse
Immunogen Synthetic peptide (N- and C- terminal peptides were used for immunisation. 1. ASGLGSPSPCSAGSEEEDM & 2. CSRLANRAPEPPPQQVAQQQ. Which peptide the antibody recognises has not been tested)
Subclass IgG2a
Myeloma Used Sp2/0-Ag14
Recommended Growing Conditions RPMI + 5% FCS
Strain CD1
Research Area Epigenetics & Nuclear Signalling, Immunology

References: 6 entries

Sparmann et al. 2013. EMBO J. 32(11):1598-612. PMID: 23624931.

The chromodomain helicase Chd4 is required for Polycomb-mediated inhibition of astroglial differentiation.

Europe PMC ID: 23624931

Curtis et al. 2012. Mol Cell Biol. 32(7):1312-20. PMID: 22290435.

The chromatin-remodeling enzymes BRG1 and CHD4 antagonistically regulate vascular Wnt signaling.

Europe PMC ID: 22290435

Ramírez et al. 2009. Epigenetics. 4(8):532-6. PMID: 19923891.

The Mi-2/NuRD complex: a critical epigenetic regulator of hematopoietic development, differentiation and cancer.

Europe PMC ID: 19923891


Add a reference

References: 6 entries

Sparmann et al. 2013. EMBO J. 32(11):1598-612. PMID: 23624931.

The chromodomain helicase Chd4 is required for Polycomb-mediated inhibition of astroglial differentiation.

Europe PMC ID: 23624931

Curtis et al. 2012. Mol Cell Biol. 32(7):1312-20. PMID: 22290435.

The chromatin-remodeling enzymes BRG1 and CHD4 antagonistically regulate vascular Wnt signaling.

Europe PMC ID: 22290435

Ramírez et al. 2009. Epigenetics. 4(8):532-6. PMID: 19923891.

The Mi-2/NuRD complex: a critical epigenetic regulator of hematopoietic development, differentiation and cancer.

Europe PMC ID: 19923891


Add a reference

References: 6 entries

Sparmann et al. 2013. EMBO J. 32(11):1598-612. PMID: 23624931.

The chromodomain helicase Chd4 is required for Polycomb-mediated inhibition of astroglial differentiation.

Curtis et al. 2012. Mol Cell Biol. 32(7):1312-20. PMID: 22290435.

The chromatin-remodeling enzymes BRG1 and CHD4 antagonistically regulate vascular Wnt signaling.

Ramírez et al. 2009. Epigenetics. 4(8):532-6. PMID: 19923891.

The Mi-2/NuRD complex: a critical epigenetic regulator of hematopoietic development, differentiation and cancer.


Add a reference


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